Aqueous Solubility of Poorly Water-Soluble Drug Ibuprofen in Micellar Media: Effect of Head Groups Charge
عنوان مقاله: Aqueous Solubility of Poorly Water-Soluble Drug Ibuprofen in Micellar Media: Effect of Head Groups Charge
شناسه ملی مقاله: ISPTC20_269
منتشر شده در بیستمین کنفرانس شیمی فیزیک ایران (IPCC۲۰) در سال 1396
شناسه ملی مقاله: ISPTC20_269
منتشر شده در بیستمین کنفرانس شیمی فیزیک ایران (IPCC۲۰) در سال 1396
مشخصات نویسندگان مقاله:
F Teymoori - School of Chemistry, Damghan University, Damghan, ۳۶۷۱۶-۴۱۱۶۷, Iran
M Jabbari - School of Chemistry, Damghan University, Damghan, ۳۶۷۱۶-۴۱۱۶۷, Iran
خلاصه مقاله:
F Teymoori - School of Chemistry, Damghan University, Damghan, ۳۶۷۱۶-۴۱۱۶۷, Iran
M Jabbari - School of Chemistry, Damghan University, Damghan, ۳۶۷۱۶-۴۱۱۶۷, Iran
In this study, equilibrium solubility of ibuprofen (IBP) as a poorly water-soluble drug was determined inpure water and in aqueous micellar solutions consisting of anionic SDS, cationic CTAB and non-ionic Brij-35surfactants with different concentrations and charged head groups. The solubility data show that, irrespective of thesurfactant type, the solubility of IBP in the micellar media increased compared to water by increasing solutionconcentration. Moreover, the non-ionic surfactant Brij-35 in lower concentrations than ionic surfactants CTAB andSDS can solve the drug ibuprofen better. This behaviour is a consequence of the interactions between the drug and themicelles under study.
کلمات کلیدی: Ibuprofen; Solubility; Micellar effect; Aqueous media
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/741999/