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SESAME SEED AND ITS FRACTIONS FOR IMPROVING OXIDATIVE STRESS IN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIALS

عنوان مقاله: SESAME SEED AND ITS FRACTIONS FOR IMPROVING OXIDATIVE STRESS IN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIALS
شناسه ملی مقاله: INC15_354
منتشر شده در سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران در سال 1397
مشخصات نویسندگان مقاله:

Fatemeh Moghtaderi - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran
Nahid Ramezani-Jolfaie - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran
Hamidreza Raeisi-Dehkordi - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran
Amin Salehi Abargouei - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran

خلاصه مقاله:
Background and Aim: It is proposed that sesame products affect oxidative stress, although the findings were inconsistent. This study aimed to summarize the effect of sesame seed and its fractions on oxidative stress parameters in human adults using systematic review and meta-analysis. Methods: PubMed, Scopus, ISI Web of Science and Google Scholar were searched up to April 2018 to identify relevant controlled clinical trials. Random effects model was used for calculating the overall effects.Results: Fifteen clinical trials were eligible. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-caroten and glutathione) antioxidants (P<0.05). It was shown that malondialdehyde levels significantly decreases only when sesame seeds were used for supplementation. However, no significant effect was observed on malondialdehyde (MDA) (Hedges g=-0.80, 95% confidence interval (CI): -1.69, 0.09; P=0.078), total antioxidant capacity (WMD=0.16, 95% CI: -0.19, 0.51; P=0.365) and α-tocopherol (WMD=-0.33, 95% CI: -1.11, 0.45; P=0.409) levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation (Hedges g = -0.82, 95% CI: -1.24, -0.40, P<0.001).Conclusion: Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.

کلمات کلیدی:
Sesame seed; Sesame fractions; Oxidative stress; Systematic Review; Meta-analysis

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/816388/