Mohammad Haghighi - Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Poursina hospital, Rasht, Iran
Hossein Ettehad - Guilan University of Medical Sciences (GUMS), Orthopedic Research Center, Poursina hospital, Rasht, Iran
Mohsen Mardani-kivi - Guilan University of Medical Sciences (GUMS), Orthopedic Research Center, Poursina hospital, Rasht, Iran
Ahmadreza Mirbolook - Guilan University of Medical Sciences (GUMS), Orthopedic Research Center, Poursina hospital, Rasht, Iran

Background:Proximal Femoral shaft fractures are commonly associated with marked blood loss which can lead topostoperative acute anemia and some other complications.Tranexamic acid (TA) is an antifibrinolytic medication that reduces intra-and postoperative blood loss and transfusionrequirements during some elective surgeries (1-3).The aim of this study is to evaluate the effect of intravenous Tranexamic acid (TA) on intraoperative blood loss and asubsequent need for transfusion in patients who were undergoing surgery for femoral shaft fractures in trauma setting.Methods:Thirty-eight ASA grade I-II patients undergoing proximal femoral shaft fracture surgery with intra medullarynailing were included in this double blind randomized controlled clinical trial. They were allocated into two groups. GroupI, the intervention group with eighteen patients received 15 mg/kg (TA) via intravenous infusion before surgical incision.Patients in the placebo group received an identical volume of normal saline.Hemoglobin level was measured four hours before and after the surgeries. Postoperative blood loss and hemoglobinchange as well as transfusion rates and volumes were compared between the two groups.Results:Mean Percentage fall in hemoglobin after surgery were 1.75±0.84 and 2.04±1.9 in the study and placebo groups,respectively (P=0.570). Hemoglobin loss was higher in the placebo group. Transfusion rates was lower in TA group(5.6%) compared to the placebo group (30%) (P=0.06). No significant difference in The Allowable Blood Loss during thesurgery was found between the two groups (P=0.894).Conclusion:Preoperative treatment with TA reduces postoperative blood loss and the need for blood transfusion duringtraumatic femoral fracture operation.

Blood loss, Blood transfusion, Femoral fracture, Tranexamic acid