Majid Mirsadraee - Department of Internal medicine, Faculty of Medicine, Islamic Azad University-Mashhad Branch, Mashhad, Iran
Afsaneh Tavakoli - Innovative Medical Research Center, Department of pharmacology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Vahideh Ghorani - Neurogenic Inflammation Research Centre and Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Shadi Ghafari - Biologist, Shahid Hasehemi Nezhad Research center, Kavosh high school, Ministry of Education, Mashhad, Iran

Objective: The present study aimed to determine the effects of Rosmarinus officinalis (R. officinalis) and Platanus orientalis(P. orientalis) extracts on asthma. Materials and Methods: We conducted a randomized, double-blind, active-comparator study to evaluate the effect of P. orientalis and R. officinalis extracts on asthmatic patients resistant to routine treatment.The subjects were randomly divided into three groups receiving P. orientalis and R. officinalis extracts alone or in combination. The primary endpoints were clinical findings, spirometry, exhaled nitric oxide (FENO) and Asthma Control Test (ACT) assessed over the one-month treatment period. Results: ACT score showed significant improvement after treatment with R. officinalis (p<0.05) but not with P. orientalis. Clinical evaluations showed that cough, sputum production and wheezing were significantly improved in R. officinalis group (p Conclusion: R. officinalis extract showed promising results in treatment of resistant asthma. Further studies to find the most effective components of these herbal medicines are recommended.

Asthma, R. officinalis, P. orientalis, Sycamore, Rosmarinic acid