Hadi Khodadadi - Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Roghayeh Pakdel - Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Majid Khazaei - Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Saeed Niazmand - Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of Portulaca oleracea (P. oleracea) seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism. Materials and Methods: Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline. T4-Po groups were given T4 plus 100, 200, and 400 mg/kg of P. oleracea seeds extract in drinking water daily. T4-Vit C group received T4 plus daily injection of Vitamin C (100 mg/kg). At the end of the experiment, body weight, serum free T4 level, left ventricular developed pressure (LVDP), malondialdehyde (MDA) and total thiol levels were measured. Results: Free T4 levels were increased in all groups that were treated with T4. Weight gain was decreased in T4 and T4-Po100 groups compared to control group (p Conclusion: The results showed that P. oleracea extract has a protective effect on cardiac dysfunction due to subclinical hyperthyroidism induced by levothyroxine sodium in rats.

Portulaca oleracea seeds, Vitamin C, Heart, Subclinical hyperthyroidism, Rat