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The combination of Coffee and tamoxifen is effective against breast cancer

عنوان مقاله: The combination of Coffee and tamoxifen is effective against breast cancer
شناسه ملی مقاله: ICBCMED14_017
منتشر شده در چهاردهمین کنگره بین المللی سرطان پستان در سال 1397
مشخصات نویسندگان مقاله:

Ghadiriyan Shahrazad - Department of biochemistry, Faculty of Advanced Technologies, pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Ghadiriyan Shahrazad - Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Jafarzadeh Mehrzad - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
Mohammad Najafi - Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

خلاصه مقاله:
Introduction & Aim: Breast cancer is the biggest health threat to women. Tamoxifen is a non-steroidal anti-estrogen that is widely used to treat breast cancer. Combination therapies are one of the therapeutic strategies that can help enhance the performance, reduce the dose, and shorten the consumption period of tamoxifen. This study aimed to investigate the synergistic effect of tamoxifen and coffee on the MCF-7 into BALB/c mice. Methods: Female Balb/c mice (5-7 weeks old) were used in this study. Tumors were established using MCF-7tumor transplantation method. Treatment began after two weeks, when tumors reached an appropriate size, the first, second, and third groups of BALB/c mice were injected with 17beta-estradiol and tamoxifen dissolved in dimethyl sulfoxide (DMSO). coffee and tamoxifen at doses at doses of 2, 5, 10, and 20 μM, of 10, 50,100 and 200 μM, and PBS over a 14-day period respectively. Then, the tumor volume was measured using a caliper. TUNEL assay kit was used to detect apoptosis. Results: Data were analyzed using the one-way analysis of variance (ANOVA). The results showed a significant difference between the negative control group and tamoxifen-treated group in terms of the simultaneous injection of coffee extract and tamoxifen (P<0.05). The results also showed increased apoptosis in this synergy.Conclusion: Tamoxifen prevents estrogen from binding to cancer cells, thus stopping cancer cell growth. This study aimed to investigate the synergistic effect of tamoxifen and coffee. The results of this study are consistent with this finding and apoptosis has increased.

کلمات کلیدی:
Tamoxifen, coffee, Breast Cancer, hormonotherapy

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/912385/