Reza Alizadeh - Department of chemistry, faculty of science, University of Qom, Qom, Iran
Sepideh Mashakiyan Dezfuli - Department of chemistry, faculty of science, University of Qom, Qom, Iran
Farzaneh Tahmasebi - Department of chemistry, faculty of science, University of Qom, Qom, Iran

Due to the nontoxic and highly porosity, MOFs based on iron(III) was applied as sorbent. The Fe3O[C6H4(CO2)2]3.nH2O is constructed from oxygen-centered iron(III) carboxylate trimer molecular building blocks, which are linked together through terephthalic acid and was prepared with hydrothermal method[1]. Resulted Nanorods coating is as sorbent phase on the fused silica fiber as novel solid phase microextraction. The SEM images with scanning electron microscopy conforms the formation nanorods (100-200 nm diameter) with high surface area[2]. The headspace solid phase microextraction (HS-SPME) method was applied for pre-concentration and analysis some cancer biomarkers included 1,2,4-trimethyl benzene, phenol, 2-pentanon from urine samples for testing the selectivity of the prepared fiber[3]. The variables affected on the extraction efficiency were optimized by experimental design method. The variables are extraction temperature and time, pH, salt% (w/v) and desorption time [4]. The calibration curves were obtained in the concentration range from 10-350 ppb for all targets. The limits of detection and limit of quantitation values were achieved 1 μg l-1 and 10 μg l-1 for 1,2,4-trimethyl benzene same as 2-pentanon and 5 μg l-1 and 50 μg l-1 for phenol, respectively. The relative standard deviations was calculated for one fiber and fiber to fiber in the range 3-15%. Finally the results obtained suggested Fe3O[C6H4(CO2)2]3.nH2O SPME fiber can be used for extraction of biomarkers from urine samples in the use of analysis cancer diagnostic and environmental compounds.