Maged Abdel Galil Hamed - Radiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Ahmed Fathy Abdel Ghany - Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Introduction:Brain imaging with F-18 fluorodeoxyglucose (18F-FDG) positron ‎emission tomography or Tc-99m hexamethylpropyleneamine oxime (‎99mTc-HMPAO) SPECT is widely used for the evaluation of Alzheimer s ‎dementia (AD); we aim to assess superiority of one method over the ‎other. Methods: Twenty four patients with clinical diagnosis of Alzheimer disease ‎underwent 18F-FDG PET and ‎99mTc-HMPAO SPECT in order to ‎assess the zones of hypo metabolism & hypoperfusion specific for ‎Alzheimer s disease. Results: 18F-FDG PET showed specific zones of ‎hypometabolism in 19 patients (79.1%) while SPECT was positive in 15 ‎cases (62.5%) with statistically significant difference (P= 0.027). Conclusion: 18F-FDG PET was significantly superior to HMPAO ‎SPECT and 18F-FDG PET could replace the classic role of perfusion ‎SPECT in diagnosis of Alzheimer s disease.

PET, SPECT, HMPAO, Alzheimer s disease