ورود
مقالات فارسیISIکنفرانسهاژورنالها

Production, formulation, quality control and primary biological studies of [18F]KF for skeletal PET scanning [Persian]

محل انتشار: مجله پزشکی هسته ای ایران، دوره: 12، شماره: 1
سال انتشار: 1383
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 231

فایل این مقاله در 13 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1008430

شناسه ملی سند علمی:

JR_IRJNM-12-1_006

تاریخ نمایه سازی: 27 فروردین 1399

چکیده مقاله:

[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O> 95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.

کلیدواژه ها:

cyclotron ، Tissue distribution ، F-18 (18F) ، Potassium fluoride ، Positron emission tomography

نویسندگان

Amir Reza Jalilian

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Mohammad Mirzaie

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Pezhman Rowshanfarzad

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Mohammad Reza Ensaf

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran