Mixed ligand metal-organic frameworks of Zr-MOFs for 3-CRs synthesis pyrazolophthalazine boosting sono-power

Zirconium cluster based MOFs because of their good thermal and chemical stability in acid, water and a number of organic solvents [1, 2]. Different formative of these frameworks are provided with ligands containing different functional groups such as hydroxyls, amines, nitrogen and halogens [3]. UIO-66 is a zirconium-based network that is used most often and consists of cationic Zr6O4(OH)4 heads (from the in situ hydrolysis of ZrCl4) with benzenedicarboxylate, thus can function as a favourable support for encapsulating active catalytic species. Herein, mixed ligand metal-organic frameworks of zirconium (UiO-66) containing terephthalic acid (H2BDC) and 2-amino terephthalic acid (H2BDC/NH2) ligands were prepared under ultrasound irradiation. FT-IR analysis, scanning electron microscope (SEM), X-ray diffraction, and EDX were incorporated for the characterization of MOFs. Then, the Zr-MOFs represented a green and highly reusable catalyst for the ultrasound-assisted one pot synthesis of pyrazolophthalazine derivatives. The mild reaction condition, high yield, easy product separation and catalyst reusability for 6 cycles were the outstanding features of this method.