ورود
مقالات فارسیISIکنفرانسهاژورنالها

The protective effects of curcumin and curmumin nanomicelle against cirrhotic cardiomyopathy in bile duct-ligated rats

محل انتشار: مجله علوم نانو، دوره: 7، شماره: 2
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 398

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1029737

شناسه ملی سند علمی:

JR_NAMJ-7-2_009

تاریخ نمایه سازی: 23 تیر 1399

چکیده مقاله:

Objective(s): Cirrhotic cardiomyopathy refers to cardiac muscle dysfunction caused by liver cirrhosis. Seemingly, free radicals and inflammatory factors play a critical role in the pathophysiology of cardiomyopathy. Curcumin has the anti-inflammatory, antioxidant, and anticancer properties . However, the therapeutic indications of this compound are limited due to its low absorption, rapid metabolism, and low bioavailability. Curcumin nanomicelle is a form of nanoparticle developed to overcome the poor kinetic profile of curcumin and enhance its bioavailability and therapeutic effects. The present study aimed to develop an experimental model of cirrhosis induced by biliary duct ligation in rats. Materials and Methods: The animals were kept until 28 days after the bile duct ligation and received curcumin or curcumin nanomicelle via oral gavage at various doses during days 7-28. After the intervention, the effects of curcumin and curcumin nanomicelle on cardiovascular function, some inflammatory and antioxidant biomarkers, and histopathological changes were assessed. Results: According to the findings, cardiac electrophysiology function and contractile force improved only in the curcumin nanomicelle groups. In addition, curcumin nanomicelle significantly reduced inflammatory factors and increased antioxidant enzymes. In the histopathological studies, cardiac tissue damage and destruction were observed to decrease in the curcumin nanomicelle groups. Conclusion: Therefore, it was concluded that curcumin nanomicelle plays a protective role in cirrhotic cardiomyopathy by reducing inflammatory and oxidative factors and improving the cardiac function. Furthermore, curcumin nanomicelle exhibited more significant therapeutic effects compared to the curcumin treatment groups.

کلیدواژه ها:

Cirrhosis ، Cardiomyopathy ، Curcumin ، Nanomicelle ، Inflammation

نویسندگان

Mohammad Sheibani

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran| Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Ahmad Reza Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran| Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Sadaf Nezamoleslami

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Seyedeh Elaheh Mousavi

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Davies M. The cardiomyopathies: an overview. Heart. 2000; 83(4): 469-674. ...
  • Wexler R, Elton T, Pleister A, Feldman D. Cardiomyopathy: an ...
  • Wong F. Cirrhotic cardiomyopathy. Hepatol Int. 2009; 3(1): 294-304. ...
  • Møller S, Lee SS. Cirrhotic cardiomyopathy. J Hepatol. 2018; 69(4): ...
  • Møller S, Bernardi M. Interactions of the heart and the ...
  • Regan TJ, Levinson GE, Oldewurtel HA, Frank MJ, Weisse AB, ...
  • Ingles AC, Hernandez I, Garcia-Estan J, Quesada T, Carbonell LF. ...
  • Pacher P, Bátkai S, Kunos G. Cirrhotic cardiomyopathy: an endocannabinoid ...
  • Chayanupatkul M, Liangpunsakul S. Cirrhotic cardiomyopathy: review of pathophysiology and ...
  • Liu H, Song D, Lee SS. Cirrhotic cardiomyopathy. Gastroenterol Clin ...
  • Gaskari SA, Honar H, Lee SS. Therapy insight: cirrhotic cardiomyopathy. ...
  • van Obbergh L, Vallieres Y, Blaise G. Cardiac modifications occurring ...
  • Ward CA, Liu H, Lee SS. Altered cellular calcium regulatory ...
  • Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: ...
  • Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component ...
  • Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta medica. ...
  • Nisenberg O. Targeted Overexpression of S-adenosylmethionine Decarboxylase in Murine Hearts. ...
  • Foti MC. Antioxidant properties of phenols. J Pharm Pharmacol. 2007; ...
  • Kapakos G, Youreva V, Srivastava AK. Cardiovascular protection by curcumin: ...
  • Yu W, Wu J, Cai F, Xiang J, Zha W, ...
  • Hewlings SJ, Kalman DS. Curcumin: a review of its’ effects ...
  • Lavan DA, McGuire T, Langer R. Small-scale systems for in ...
  • Cavalcanti A, Shirinzadeh B, Freitas Jr RA, Hogg T. Nanorobot ...
  • Mitra AK, Cholkar K, Mandal A. Emerging nanotechnologies for diagnostics, ...
  • Rezayat S. The protective effect of nano-curcumin in experimental model ...
  • Dolati S, Ahmadi M, Aghebti-Maleki L, Nikmaram A, Marofi F, ...
  • Tarcin O, Basaranoglu M, Tahan V, Tahan G, Sücüllü I, ...
  • Mani AR, Ippolito S, Ollosson R, Moore KP. Nitration of ...
  • Garrido M, Escobar C, Zamora C, Rejas C, Varas J, ...
  • Yang Y, Chen B, Chen Y, Zu B, Yi B, ...
  • Gaskari SA, Liu H, Moezi L, Li Y, Baik SK, ...
  • Bruck R, Ashkenazi M, Weiss S, Goldiner I, Shapiro H, ...
  • Li L, Duan M, Chen W, Jiang A, Li X, ...
  • Moore K, Roberts LJ. Measurement of lipid peroxidation. Free Radic ...
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides ...
  • Ighodaro O, Akinloye O. First line defence antioxidants-superoxide dismutase (SOD), ...
  • Haq MM, Legha SS, Choksi J, Hortobagyi GN, Benjamin RS, ...
  • Yarmohmmadi F, Rahimi N, Faghir-Ghanesefat H, Javadian N, Abdollahi A, ...
  • Sheibani M, Nezamoleslami S, Faghir-Ghanesefat H, hossein Emami A, Dehpour ...
  • Radu R, Bold A, Pop O, Mălăescu D, Gheorghişor I, ...
  • Timoh T, Protano M, Wagman G, Bloom M, Vittorio T, ...
  • Gassanov N, Caglayan E, Semmo N, Massenkeil G, Er F. ...
  • Møller S, Hove JD, Dixen U, Bendtsen F. New insights ...
  • Liu H, Lee SS. Nuclear factor‐κB inhibition improves myocardial contractility ...
  • Sánchez-Fidalgo S, Cárdeno A, Villegas I, Talero E, de la ...
  • Bereswill S, Muñoz M, Fischer A, Plickert R, Haag L-M, ...
  • Mošovská S, Petáková P, Kaliňák M, Mikulajová A. Antioxidant properties ...
  • Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. ...
  • Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of ...
  • Hatamipour M, Sahebkar A, Alavizadeh SH, Dorri M, Jaafari MR. ...
  • Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri‐Asl ...
  • Sundar Dhilip Kumar S, Houreld NN, Abrahamse H. Therapeutic potential ...
  • Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S, Oskuee RK. ...
  • Fourlas CA, Alexopoulou AA. Cirrhotic cardiomyopathy. Hellenic J Cardiol. 2004; ...
  • Karagiannakis DS, Vlachogiannakos J, Anastasiadis G, Vafiadis-Zouboulis I, Ladas SD. ...
  • Behrendt P, Preusse-Prange A, Klüter T, Haake M, Rolauffs B, ...
  • Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B. ...
  • Hellenbrand DJ, Reichl KA, Travis BJ, Filipp ME, Khalil AS, ...
  • Khan J, Noboru N, Young A, Thomas D. Pro and ...
  • Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, ...
  • Amirshahrokhi K, Ghazi-Khansari M, Mohammadi-Farani A, Karimian G. Effect of ...
  • Niki E. Lipid peroxidation products as oxidative stress biomarkers. Biofactors. ...
  • Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) ...
  • Wolf G. The discovery of the antioxidant function of vitamin ...
  • Lobo V, Patil A, Phatak A, Chandra N. Free radicals, ...
  • Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, ...
  • Hwang C, Sinskey AJ, Lodish HF. Oxidized redox state of ...
  • Wang X-L, Li T, Li J-H, Miao S-Y, Xiao X-Z. ...
  • Lebovitz RM, Zhang H, Vogel H, Cartwright J, Dionne L, ...
    • نمایش کامل مراجع