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Comparison of the effects of intramyocardial and intravenous injections of human mesenchymal stem cells on cardiac regeneration after heart failure

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 23، شماره: 7
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 330

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لینک ثابت به این مقاله:
https://civilica.com/doc/1038507

شناسه ملی سند علمی:

JR_IJBMS-23-7_007

تاریخ نمایه سازی: 27 مرداد 1399

چکیده مقاله:

Objective(s): Existing studies have demonstrated that intravenous and intramyocardial-administrated mesenchymal stem cells (MSCs) lead to tissue repair after cardiac disorders. We compared the efficiency of both administration methods.Materials and Methods: A rat model of isoproterenol-induced heart failure (ISO-HF) was established to compare the effects of intravenous and intramyocardial-administrated MSCs on cardiac fibrosis and function. The animals were randomly assigned into six groups: i) control or normal, ii) ISO-HF (HF) iii) ISO-HF rats treated with intramyocardial administration of culture medium (HF+IM/CM), iv) ISO-HF rats treated with intravenous administration of culture medium ( HF+IV/CM), v) ISO-HF rats treated with intravenous administration of MSCs (HF+IV/MSCs), vi) ISO-HF rats treated with intramyocardial administration of MSCs ( HF+IM/MSCs). Cultured MSCs and culture medium were administrated at 4 weeks after final injection of ISO. Heart function, identification of MSCs, osteogenic differentiation, adipogenic differentiation, cardiac fibrosis and tissue damage were evaluated by echocardiography, flow-cytometery, von Kossa, oil red O, Masson’s trichrome and H & E staining, respectively. Results: Both intravenous and intramyocardial MSCs therapy significantly improved heart function and reduced cardiac fibrosis and tissue damage (P<0.05), whereas the cultured medium had no beneficial effects. Conclusion: In sum, our results confirm the validity of both administration methods in recovery of HF, but more future research is required.

کلیدواژه ها:

Heart function ، Intramyocardial injection ، Intravenous injection ، Isoproterenol-induced heart failure ، Mesenchymal stem cells

نویسندگان

Behnaz Mokhtari

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Nahid Aboutaleb

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Donya Nazarinia

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Mahin Nikougoftar

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

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