The Effects of Mesenchymal Stem Cells on Tumors and Cancers

Introduction: Cancer is One of the Most Important Causes of Mortality in the Developed World. In General, an Uncontrolled Growth of Cells and the Absence of Apoptosis or the Gradual Death of Cells Cause Cancer. The Use of Stem Cells in Immuno-Modulation or Reconstitution is One of the Methods that has been Used for Decades in Cancer Therapy. Stem Cells have Self-Renewal Capacity with Highly Replicative Potential in Multilineage Differentiation Capacity and can be Divided into Three Main Categories, Including Embryonic, Germinal, and Somatic. But in this Way We have Different Problems Because Stem Cell have a Different Reactions.Description: In the Current Literature Review Keywords Including Cancer, Tumors, Apoptosis, Angiogenesis and Mesenchymal Stem Cell from the List of MeSH and other Credible Scientific Websites such as Science Direct, PubMed and Google Scholar were used to Compile the Effects of Stem Cell on Cancers and Tumors.Discussion and conclusion: Studies Show that MSCs has a Different Impact on Tumors and Cancer. MSCs can have an Impact on the Tumor Sites, Resulting in the Promotion of Tumor Growth and Angiogenesis through Differentiating into Cancer-Associated Myofibroblasts and Secretion of Proangiogenic and Enhanced Tumor Metastasis by Increasing Lysyl Oxidase. In addition, MSCs can Inhibit Natural killer Cell and Cytotoxic T Lymphocyte Functions in Breast Cancer. Studies have Demonstrated that Human Umbilical Cord MSCs can Promote the Growth of Lung Adenocarcinoma Cancer Cells by Transferring miRNAs. In Contrast, MSCs have Antitumor Effects in Different Animal Models of Cancers. MSCs can Suppress the Proliferation of Glioma, Melanoma, Hepatoma, and Breast Cancer Cells. It also has Some Antiglioma Effects through Inhibiting Vascular Growth in Glioma Cells. Moreover, Human Bone Marrow-Derived MSCs have the Potential to Suppress the Growth of Breast Cancer and Inhibit Lung Metastasis by Reducing their Proliferative Ability.