Silybum Marianum for Wound Healing

Introduction: Silybum marianum has an uncurled, pale green plant, with red to purple flowers. There are a lot of compounds in this plant, including such as saline, silymarin, apigenin, and et. Silymarin is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans and one flavonoid. Poor water solubility and bioavailability of silymarin led to the development of enhanced formulations.Description: In the context of this overview, 12 articles were used between the years 2010 through the end of 2018 using the Keywords of PubMed, Google and Google scholar search engines.Discussion and conclusion: One of the goals of medical science is wound healing in shorter time and with less side effects. The results indicate that the extracts of Silybum Marianum accelerate the repair and restoring process of the wound;Silibinin affects collagen synthesis. Silymarin improves epithelization and it has no effect on the percentage of wound contraction. Several studies demonstrated that Silybum Marianum due to anti-inflammatory substances, has an important effect on the first phase of wound healing.However, the study of the effects of its active compounds on wound healing and tissue engineering can be important.