Application of 3D Bio-Printing in Regenerative medicine and Tissue Engineering

Introduction: 3D printing technology is now recognized as a novel and advanced approach in regenerative medicine as it is capable of overcoming the limitations associated with other conventional processing methods. This technology enables the creation of a structure with cells, synthetic and natural biomaterials, growth factors and biomolecules in a 3D construct with the aim of mimicking natural tissue structure.Description: In tissue engineering, the use of advanced tools and technology with the ability to fabricate and manage layer by layer structures can be an effective approach in the success of tissue reconstruction and repair of the defected site. 3D printing technology, utilizing cells embedded in a hydrogel, are able to create an extracellular matrix structure similar to the host tissue. They are various parameters that contribute to printer’s biological ink (Bio-ink) such as type and concentration of the polymer and the solvent. All of the effective parameters in 3D bio-printing is thoroughly discussed.Discussion and Conclusion: One of the most recent advances in biomedicine is the application of 3D biomaterials processing method which can enable the creation of a patient-specific construct. At present, although the clinical applications of 3D printer face limitations and challenges, but such structures are capable of angiogenesis and differentiation and the direct growth in the near future.