Industrially manufacturing process for the synthesis of Azithromycin dihydrate, as an effective macrolide antibiotic

The present study describes a high yield procedure for the industrially production of the Azithromycin in itscrystalline dihydrate form. The physicochemical properties of synthesized sample were investigated using variousanalyses methods, including XRD, KFT, UV–vis, FTIR, 1H and 13C NMR and HPLC. This procedure represented anacceptable yield about 1.00 (based on Aza-Erythromycin weight) with 98.7% purity of Azithromycin dihydrate.