Clinicopathological Significance of Tumor Stem Cell Markers ALDH1 and CD133 in Colorectal Carcinoma
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 16، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 270
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شناسه ملی سند علمی:
JR_IJP-16-1_005
تاریخ نمایه سازی: 26 آذر 1399
چکیده مقاله:
Background & Objective: Colorectal cancer (CRC) is the third most common cancer worldwide with a high mortality rate. The main causes of death in patients are recurrence and metastasis which are mainly attributed to the small subpopulation of cells within tumors called cancer stem cells (CSCs). This study aimed to evaluate the correlation between the expression of AHDL1 and CD133 as CSC associated markers and clinicopathological characteristics in CRC. Methods: In this cross-sectional study, a total of 483 CRC tumor samples were immunohistochemically stained for detection of CD133 and ALDH1 markers. Correlations of marker expression with clinicopathological factors were also evaluated. Results: There was a significant correlation between the luminal intensity of CD133 and neural invasion (p =0.05) and between the cytoplasmic intensity of CD133 and metastasis (p =0.05). In terms of H-score, a positive significant relation was observed between cytoplasmic expression of CD133 and lymph node (p =0.02), neural (p =0.04) and vascular invasion (p =0.02). The ALDH1 cytoplasmic expression showed a significant correlation with tumor size (p =0.001). Conclusion: Our findings showed that increased expression of CD133 and ALDH1 is associated with tumor progression and worse outcomes in CRC patients. These markers can be good candidates for localized targeting of CSCs using antibodies. Future researches need to be improved approaches for early detection of CRC, and treatment monitoring for CRC and other cancers.
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نویسندگان
maryam Rezaee
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
Elmira Gheytanchi
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
Zahra Madjd
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
Mitra Mehrazma
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
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