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مقالات فارسیISIکنفرانسهاژورنالها

Prevalence and Main Determinants of BRAF V600E Mutation in Dysplastic and Congenital Nevi

محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 16، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 258

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1130687

شناسه ملی سند علمی:

JR_IJP-16-1_006

تاریخ نمایه سازی: 26 آذر 1399

چکیده مقاله:

Background & Objective: Predicting the transformation of dysplastic or congenital nevi into malignant lesions results in a significant increase in the survival of patients. Some specific gene mutations have been reported to be very helpful in this regard. Therefore, this study aimed to evaluate the prevalence of BRAF V600E mutation in dysplastic and congenital nevi. Methods: This cross-sectional study was conducted on patients with congenital (n=30) or dysplastic (n=30) nevi. For genomic analysis, the BRAF gene mutation (V600E) was evaluated using the real-time polymerase chain reaction. Results: The prevalence of BRAF gene (V600E) mutation was found as 1 case (3.3%) in congenital and 8 cases (26.7%) in dysplastic nevi indicating the higher prevalence of this mutation in patients with dysplastic nevi (p =0.026). Moreover, in the dysplastic nevi group, the presence of BRAF gene mutation (V600E) showed  a significant relationship with the severity of dysplasia as the mutation rate was 25% in mild cases, in comparison with 54.5% in moderate dysplasia cases (p =0.009). Conclusion: According to the results, 3.3% of the patients with congenital nevi and 26.7% of the subjects with dysplastic nevi were positive for BRAF V600E mutation. Furthermore, the severity of dysplasia could have a positive relationship with the presence of the mutation.

کلیدواژه ها:

BRAF mutation ، Congenital nevi ، Dysplastic nevi

نویسندگان

Maryam Nasimi

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

alireza Ghanadan

Department of Dermatopathology, Razi Hospital, Pathology Department of Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Kambiz Kamyab

Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

vahidesadat Azhari

Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Tahereh Yousefi

Department of Anatomical Pathology, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

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  • Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, ...
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