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مقالات فارسیISIکنفرانسهاژورنالها

Comparative study of gavage and intraperitoneal administration of gamma-oryzanol in alleviation/attenuation in a rat animal model of renal ischemia/reperfusion-induced injury

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 318

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1138586

شناسه ملی سند علمی:

JR_IJBMS-24-2_007

تاریخ نمایه سازی: 19 دی 1399

چکیده مقاله:

Objective(s): Ischemia/reperfusion (I/R) is the leading cause of acute kidney injury. This study aimed to elucidate the reno-protective effect of gamma-oryzanol (GO) by comparing gavage and intraperitoneal (IP) administration methods on renal I/R injury in a rat model.   Materials and Methods: Rats were divided into four groups including (group 1) sham, (group 2) I/R-control, (group 3) I/R+GO gavage-treated, and (group 4) I/R+ GO IP-treated. A single dose of GO was administrated to groups 3 and 4 (100 mg/kg body weight), 60 min before induction of I/R. After anesthesia, I/R was created by 45 min of ischemia, followed by 6 hr of reperfusion.  Then, blood and tissue samples were subjected to evaluation of renal function, anti-oxidant capacity, inflammation, apoptotic proteins, and IKB/NF-kB pathway.Results: The two GO administration methods showed improvement of renal function along with attenuation of histological abnormalities. An increase in antioxidant capacity along with a decrease in pro-inflammatory markers, decline in the expression levels of BAX, Bax/Bcl-2, and caspase-3, and up-regulation of Bcl-2 expression were recorded. Moreover, a significant decrease in NF-Kb, p-IKBα, and MMP-2/9 with an increase in IKBα levels were also observed.  Overall, in a comparative evaluation between the two gavage and IP administration methods, we did not find any differences in all examined parameters, except IL-6 which had a better result via gavage.Conclusion: A single dose of GO administration has a reno-protective effect against renal I/R injury. Gavage and IP administration exhibit similar efficiency in alleviation of I/R injury.

کلیدواژه ها:

Anti ، oxidants Gamma ، oryzanol Gavage Intraperitoneal Renal ischemia/reperfusion Signaling pathways

نویسندگان

Yasin Bagheri

Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Alireza Barati

Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Sana Nouraei

Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Nasim Jalili Namini

Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Mohammad Bakhshi

Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Ezzatollah Fathi

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Soheila Montazersaheb

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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