ورود
مقالات فارسیISIکنفرانسهاژورنالها

Increased expression of PD-1 on CD4+ T cells subsets in Rheumatoid Arthritis patients

محل انتشار: فصلنامه زیست پزشکی جرجانی، دوره: 7، شماره: 2
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 197

فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1153635

شناسه ملی سند علمی:

JR_JOBJ-7-2_007

تاریخ نمایه سازی: 27 بهمن 1399

چکیده مقاله:

Study objectives: Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease, characterized by inflammation and the destruction of the joints. It is well known that CD4+ T cells play a major role in the pathogenesis of RA. Expanded subpopulations of CD4+ T cells have been reported in RA patients. Here, we investigated the expression of PD-1 on subsets of CD4+ T cells (CD4+CD28- and CD4+CD28+ T cells) in the peripheral blood (PB) and synovial fluid (SF) of patients with RA. Methods: A total of 42 RA patients, including 10 newly diagnosed (ND) and 32 relapsed (RL) cases and also 20 healthy controls were enrolled. Phenotypic characterization subsets of CD4+ T cells were evaluated by flow cytometry, using fluorescence conjugated specific human monoclonal antibodies. Results: The frequency of CD4+CD28+ T cells was significantly increased in SF versus PB in ND and RL patients. In contrast, the percentage of CD4+CD28- T cells was elevated in PB of ND and RL patients comparison to SF. Expression of PD-1 on CD4+CD28+ and CD4+CD28- T cells in PB of ND and RL patients was significantly higher than the healthy controls. Furthermore, PD-1 expression on CD4+CD28+ and CD4+CD28- T cells in SF versus PB of RL patients were significant increased. Conclusion: These data suggest that CD4+ T cells subsets in RA patients were resistance to PD-1 mediated effects and PD-1 has insufficient ability to suppression of CD4+T cells.

کلیدواژه ها:

CD4+CD28+ T cells ، CD4+CD28- T cells ، CXCR3 ، PD-1 ، Rheumatoid Arthritis

نویسندگان

faezeh ajam

Student Research Committee, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Mehrdad Aghaei

Golestan Rheumatology Research Center (GRRC), Golestan University of Medical Sciences, Gorgan, Iran

Saeed Mohammadi

Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Mohsen Saeedi

Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Nasser Behnampour

Public Health Department, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran

Ali Memarian

Golestan Rheumatology Research Center (GRRC), Golestan University of Medical Sciences, Gorgan, IranGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • García‐Vicuña R, Gómez‐Gaviro MV, Domínguez‐Luis MJ, Pec MK, González‐Alvaro I, ...
  • Lin SC, Yen JH, Tsai JJ, Tsai WC, Ou TT, ...
  • Li S, Liao W, Chen M, Shan S, Song Y, ...
  • Gravallese EM, Manning C, Tsay A, Naito A, Pan C, ...
  • Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, ...
  • Janossy G, Duke O, Poulter L, Panayi G, Bofill M, ...
  • Zhang X, Nakajima T, Goronzy JJ, Weyand CM. Tissue trafficking ...
  • Herman S, Zurgil N, Langevitz P, Ehrenfeld M, Deutsch M. ...
  • Pieper J, Johansson S, Snir O, Linton L, Rieck M, ...
  • Strickland FM, Patel D, Khanna D, Somers E, Robida AM, ...
  • Bartosińska J, Zakrzewska E, Krol A, Raczkiewicz D, Purkot J, ...
  • Wan B, Nie H, Liu A, Feng G, He D, ...
  • Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, ...
  • Mohammadi S, Memarian A, Sedighi S, Behnampour N, Yazdani Y. ...
  • Bryl E, Vallejo AN, Matteson EL, Witkowski JM, Weyand CM, ...
  • Namekawa T, Wagner UG, Goronzy JJ, Weyand CM. Functional subsets ...
  • Warrington KJ, Takemura S, Goronzy JJ, Weyand CM. CD4+, CD28− ...
  • Schmidt D, Goronzy JJ, Weyand CM. CD4+ CD7-CD28-T cells are ...
  • El-Menoufy MA, El-Kak AE-AA, Ahmed MA. Unusual CD4+ CD28− T ...
  • Pawłowska J, Mikosik A, Soroczynska-Cybula M, Jóźwik A, Łuczkiewicz P, ...
  • Fasth AE, Snir O, Johansson AA, Nordmark B, Rahbar A, ...
  • Bommarito D, Hall C, Taams L, Corrigall V. Inflammatory cytokines ...
  • Raptopoulou AP, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, ...
  • Liu C, Jiang J, Gao L, Wang X, Hu X, ...
  • Luo Q, Ye J, Zeng L, Luo Z, Deng Z, ...
    • نمایش کامل مراجع