Histopathological and Clinical Characteristics in Patients with Triple-Negative Breast Cancer from 2016 to 2020

Background: Breast cancer (BC) is the most common cancer in women within the world. According to estimate of American Cancer Society approximately 246,660 invasive BC will be diagnosed and 40,890 deaths occurred in 2016. One of aggressive type of BC is Triple-Negative Breast cancer (TNBC) that defined as without estrogen, progesterone receptors, and Human epidermal growth factor (HER2). This study was performed to determine the histopathological and clinical characteristics of TNBC patients in hospitals in Tehran. Methods: In this cross-sectional study was performed in 5 educational and private hospitals in Tehran since 2015 to 2018. This study conducted 100 consecutive TNBC patients that were collected from their medical records. The technique that used for determination of mentioned receptors was Immunohistochemistry staining. For data analysis was used SPSS 16 with Fisher and Chi-square tests. P-value≤0.05 was considered statistically significant. Results: The mean age of patients was 49.7 (±12.2) years. 78 (81.3%) of patients were Invasive Ductal Carcinoma type with negative metastasis. There was significant relationship between Family History (p=0.001) and Lymphatic Involvement (p<0.001) with Metastasis. Negative Metastatic Lymphatic Involvement (44-95.7%) was more than positive one (16-29.6%). The number of patients with stage IIA, IIB, IIIA, IIIB, and IIIC were 32, 14, 12, 1, and 3 that were negative in metastasis respectively. Hence, the patients within type IV were 18 with positive metastasis. The number of patients with Grade II and III were 53 and 47, respectively Conclusions: In this study revealed characteristics involved age, family history, types, stage, and grade of tumor. Negative family history was significantly more than positive one (P=0.001). About stages, IIA and IIIB were significantly more and less than other stages (P˂0.001), respectively