Evaluation of the effect of vitamin C consumption in the treatment of patients with Covid-19: A systematic review

Background: To date, approximately 32 million people worldwide have been infectedwith COVID (19). In infection, the surface of Vitamin C is reduc. Vitamin C is used inseptic shock and severe infections. Inflammatory mediators in COVID-19 increases, andevidence suggests that vitamin C may reduce inflammatory mediators. So, the aim of thepresent study was to determine the effect of vitamin C in the treatment of patients withCOVID-19.Material and Methods: The present review study was conducted in 1299. To conductthis study from databases web of science, Science Direct, Google Scholar, PubMed,Scopus and SID database And by using english keywords COVID-19, Coronavirusinfection, vitamin C, clinical trial and interventional study study with no time limit. Aftersearching for articles related to persian and English studies, that the keywords were notincluded in the title or abstract or the full text of the article was not available and wereduplicates, from the study was excluded. Out of 735 articles obtained after reviewing thetitle, abstract and the whole article, 5 articles related to English (oneCase series articleand a clinical trial article) were included in the study.Results: The results of a case series study on 23 patients with a mean age of 66±4 yearsshowed that after consuming one gram of vitamin C each eight hours to three days inpatients in the ICU who were in the severe stage of the disease, Level of D-dimer (p=0/033) And ferritin (p = 0/004) decreased significantly. But despite the reduced need forFiO2 after taking vitamin C, the difference not statistically significant. In a clinical trialperformed on 65 patients with a mean age of 66±7 years vitamin C was administered at adose of 13 g every 13 hours for seven days. In this study reduced mortality in ICU(p=0/04), Decrease in interleukin-6 (p=0/01), Decreased total bilirubin (p= 0/01),Increasethe ratio PaO2/FiO2 (p=0/02) was seen. While SOFA score and index of number of daysof separation from aggressive mechanical ventilation (p=0/61) did not changesignificantly.Conclusions: According to the results of improvement studies on mortality,inflammatory criteria, coagulation, oxygen level indices, vitamin C may have a positiveeffect on the recovery of patients with COVID-19 who are in the severe stage of thedisease. On the other hand, the medication regimen that has been administered to patientsalong with vitamin C and other indicators such as age, underlying disease and pulmonaryinvolvement ratio may be influential in the outcome, hence the design of more accurateclinical trials, it is recommended to perform statistical tests to modify confoundingvariables.