Sustained release of linezolid in ocular insert based on lipophilic modified structure of sodium alginate
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 279
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شناسه ملی سند علمی:
JR_IJBMS-24-3_008
تاریخ نمایه سازی: 6 اردیبهشت 1400
چکیده مقاله:
Objective(s): Ocular inserts are usually polymeric thin films with increased ocular residence time and sustained drug release capacity. Sodium alginate is a biocompatible and biodegradable carrier; however, initial burst release of encapsulated drug within it, is recognized as a challenge. Grafting –addition of functional moieties to a polymer– is a technique to modify polymers’ physicochemical properties, including higher ability to control drug release. Linezolid (LNZ) solution is used in consecutive doses in treatment of antibiotic-resistant Gram-positive bacterial infections especially induced by methicillin resistant Staphylococcus aureus (MRSA). Materials and Methods: Grafted alginate copolymers were synthesized using butyl methacrylate (BMC) and lauryl methacrylate (LMC) at two different reaction times (۱۲ hr and ۲۴ hr). Copolymerization was evaluated by ۱H-NMR, Ft-IR, and TGA. Copolymer safety was examined by cytotoxicity test against HEK-۲۹۳ cell. Linezolid inserts were prepared using optimized copolymers and characterized.Results: ۱H-NMR, Ft-IR, and TGA confirmed the successful grafting of alginate copolymers. ALG-B۲۴ and ALG-L۱۲ showed the highest safety against HEK-۲۹۳ cell line comparing with intact alginate. Linezolid insert characterization results indicated a slower linezolid release profile related to creation of a lipophilic structure. A better strength property for linezolid loaded ALG-B۲۴ and ALG-L۱۲ inserts was obtained while ALG-L۱۲ showed a stronger adhesive force compared with intact alginate. Antibacterial efficacy on clinical isolated MRSA after ۲۴ hr was similar to linezolid solution.Conclusion: Lipophilic alginate copolymer (ALG-L۱۲) showed a sustained release capability while retaining its main feature in strong film forming ability so it seems to be a promising safe carrier.
کلیدواژه ها:
نویسندگان
Ashkan Mohammad Sadeghi
Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Farjadian
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Shohreh Alipour
Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
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