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مقالات فارسیISIکنفرانسهاژورنالها

Cytotoxicity Effect of Brevinin-۲R Peptide on Oral Squamous Cell Carcinoma

محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 24، شماره: 107
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 210

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1191725

شناسه ملی سند علمی:

JR_ZUMS-24-107_004

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

Background and Objective: Peptide as an agent in manufacturing new drugs has recently been taken into consideration. Brevinin-۲R is a nano peptide with a wide range of biological actions. Thus, the current study was designed in order to evaluate the in vitro effects of Brevinin-۲R on oral squamous cell carcinoma cells in comparison to normal mice fibroblast cells. Materials and Methods: In this study, oral squamous cell carcinoma cells (KB) and normal mice fibroblast cells (L۹۲۹) were cultured and  treated with different concentrations of Brevinin-۲R (۰.۱-۳۰ µg/ml) for ۲۴, ۴۸ and ۷۲ hours. Then, cell viability was calculated by MTT method. Data were fed to SPSS software (version ۲۰) via which One Way ANOVA and Tukey tests was calculated for the collected data. Results: The half-maximal inhibitory concentration (IC۵۰) of Brevinin-۲R for KB cells and L۹۲۹ cells were ۱۵.۴۸ and ۲۴.۱۴ µg/ml respectively, demonstrating that higher concentration of Brevinin-۲R is necessary in order to reach IC۵۰ concentration for L۹۲۹ cells (about ۱.۵ times). Conclusion: Results point out that Brevinin-۲R peptide is more effective on oral squamous cell carcinoma cells compared to normal mice fibroblast cells (L۹۲۹).

کلیدواژه ها:

Keywords: Brevinin-۲R ، Cell cytotoxic ، Oral squamous cell carcinoma ، Medical peptide

نویسندگان

فائزه خزیمه

Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

زهرا گلستان نژاد

Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

عزیزالله باختری

Dept. of Animal Sciences, Faculty of Agriculture, Isfahan University of Technology, Isfahan, Iran

مهین بخشی

Dept. of Dental Diseases, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

هژیر یوسف شاهی

Student Research Committee, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

شاهین گوانجی

Young Researchers and Elite Club, Islamic Azad University, Isfahan (khorasgan) Branch, Isfahan, Iran

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