Therapeutic Effects of Quercus persica L Fruit Skin on Healing of Second-Degree Burn Wounds in Animal Model
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 264
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شناسه ملی سند علمی:
JR_ZUMS-25-113_008
تاریخ نمایه سازی: 11 اردیبهشت 1400
چکیده مقاله:
Background and Objective: Second-degree burns are associated with several complications such as infection, septicemia, and unpleasant skin appearance and are one of the main causes of in-hospital mortality. Therefore, this study was designed to determine the therapeutic effects of Q. persica fruit skin on the healing of second-degree burn wounds.
Materials and Methods: In this experimental study, ۶۰ mice were randomly assigned into three groups. Vaseline was used for group ۱, ۱% Silver sulfadiazine (SSD) cream was used for group ۲, and Vaseline-based Quercus persica L. hydroalcoholic extract was used for group ۳. After the development of second-degree burns with a pathologist’s confirmation, the wound area was measured for a month by AutoCAD software. The wound was pathologically examined and data were analyzed by repeated measures ANOVA and Kruskal-Wallis using SPSS ۱۸.
Results: Decrease in wound area was ۷۲.۰۱% in the Quercus persica L. group, ۶۵.۹۵% in the SSD group, and ۵۹.۱۲% in the Vaseline group. Mean wound recovery was higher in the Q. persica fruit skin group but not significant (P>۰.۰۵). The mean number of wound hair follicles and sebaceous glands and mean wound angiogenesis were higher while wound inflammation intensity was lower in Quercus persica L group, but no significant difference in these variables was seen between the Quercus persica L and SSD groups (P>۰.۰۵).
Conclusion: Quercus persica L. had relatively acceptable therapeutic effects on the healing of second-degree burn wounds compared to SSD and Vaseline.
کلیدواژه ها:
نویسندگان
غلامرضا شبانیان
Dept. of Anesthesia, Shahrekord University of Medical Sciences, Shahrekord, Iran
سعید حیدری سورشجانی
Dept. of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran
محمود رفیعیان
Dept. of Pharmacology & Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
میترا سعادت
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
محمدرضا شبانیان
School of Medicine , Isfahan University of Medical Sciences, Isfahan, Iran
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