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مقالات فارسیISIکنفرانسهاژورنالها

A Study on the Effects of Perovskia abrotanoides Karel on Experimental Skin Burn in Male Rat: in-vivo and in-vitro Findings

محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 27، شماره: 122
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 212

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لینک ثابت به این مقاله:
https://civilica.com/doc/1191832

شناسه ملی سند علمی:

JR_ZUMS-27-122_003

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

Background & Objective: Perovskia abrotanoides Karel locally known as Brazambal, is widely used in medical practice to treat various disorders. Burn is a common source of injury and Brazambal ointment has been extensively used in burn wound healing in North of Iran. The purpose of this study was to examine the healing effect of Brazambal ointment in experimental model of burn. In addition, in-vitro healing characteristics and antibacterial activity of P. abrotanoides was investigated. Materials & Methods: Scald burn injury was produced by pouring ۲.۵cc of boiling water (۹۵ºC) on the posterior surface of rat’s neck for ۱۰ seconds. Twenty-eight adult male Sprague Dawley rats were divided into ۴ groups (۷ rats each) and followed for ۷ days. Control group (no treatment); Silver sulfadiazine-treated group; Brazambal ointment-treated group; and vehicle-treated group received the complete ointment without Brazambal part. The effects of Brazambal aqueous extract on fibroblast cells and antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were evaluated. Results: Topical application of Brazambal ointment can accelerate wound healing process by initiating re-epithelialization and formation of granulation tissue. Proliferative activity of the aqueous extract on fibroblast cells was observed after ۴۸ h in concentrations of ۷.۵% and ۱۰% (P<۰.۰۰۰۱). However, P. abrotanoides Karel extract had no significant antibacterial effect. Conclusion: The presence of hair follicles, re-epithelialization and granulation tissue is suggestive of Brazambal ointment relative effectiveness on experimental scald burn in rats. However, further studies are warranted to reveal the healing mechanisms of P. abrotanoides.

کلیدواژه ها:

Perovskia abrotanoides ، Brazambal ، Traditional medicine ، Burn

نویسندگان

امین درخشانفر

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

سیدسارا هاشمی

Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran

جواد موئیدی

Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran

محجوب واحدی

Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

داود مهربانی

Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz,Iran

ابوذر ولیزاده

Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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