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مقالات فارسیISIکنفرانسهاژورنالها

Antioxidant and Anti-hyperlipidemic Effects of Bark Extract of Pinus eldarica in Dexamethasone-induced Dyslipidemic Rats

محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 27، شماره: 125
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 195

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لینک ثابت به این مقاله:
https://civilica.com/doc/1191888

شناسه ملی سند علمی:

JR_ZUMS-27-125_007

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

Background & Objective: Although Pinus eldarica is considered as a pine with many valuable phytochemical constituents, little is known about the pharmacological effects of its bark extract. Therefore, the present study aimed to evaluate in vivo antioxidant activity and also the possible beneficial effects of the bark extract of P. eldarica on dexamethasone-induced dyslipidemia in rats. Materials & Methods: Total phenolic content was determined using Folin-Ciocalteu method. The in vivo antioxidant assays included the measurement of hydroperoxides level and ferric reducing antioxidant power (FRAP) value in plasma samples of rats receiving intraperitoneal injections (IP) injections of plant extract (۱۰۰, ۲۰۰ and ۴۰۰ mg/kg) for ۲۸ days. For induction of dyslipidemia, dexamethasone (۱۰ mg/kg) was subcutaneously administered during ۸ days. Different doses of extract were given orally plus dexamethasone in three groups of animals. Serum lipids, blood glucose and malondialdehyde (MDA) levels and liver histopathology were assessed. Results: High total phenolic content was determined as ۳۷۵±۱.۲ mg gallic acid equivalent/ g of dried bark extract. The extract significantly decreased plasma hydroperoxides level at all doses and increased FRAP value at the dose of ۴۰۰ mg/kg during in vivo antioxidant analysis. P. eldarica led to a significant reduction in serum levels of blood glucose, total cholesterol, triglyceride and MDA and improved liver histopathological changes at the doses of ۲۰۰ and ۴۰۰ mg/kg in dyslipidemic rats. Conclusion: These findings suggest the potential antioxidant, antihyperlipidemic and antihyperglycemic activities for the bark extract of P. eldarica which may be due to the high amounts of phenolic compounds.

کلیدواژه ها:

Antioxidants ، Dexamethasone ، Hyperlipidemias ، Lipid Peroxidation ، Pinus eldarica

نویسندگان

Leila Safaeian

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Behzad Zolfaghari

Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Najmeh Assarzadeh

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Akram Ghadirkhomi

Office for Supervision on Food, Cosmetics and Hygienic Products, Vice Chancellery for Food and Drugs, Isfahan University of Medical Sciences, Isfahan, Iran

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