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مقالات فارسیISIکنفرانسهاژورنالها

Sentinel lymph node biopsy for papillary thyroid cancer: the effect of dose, tracer and application of massage

محل انتشار: مجله پزشکی هسته ای و زیست شناسی آسیا اقیانوسیه، دوره: 9، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 247

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لینک ثابت به این مقاله:
https://civilica.com/doc/1195034

شناسه ملی سند علمی:

JR_JNMB-9-1_002

تاریخ نمایه سازی: 14 اردیبهشت 1400

چکیده مقاله:

Objective(s): In patients with papillary thyroid cancer (PTC), sentinel lymph node (SLN) radio-guided biopsy is not routinely used for detection of involved neck lymph nodes (NLN); ۹۹mTc- antimony sulfide colloid (۹۹mTc- ASC) has been used for this purpose. In this study, besides ۹۹mTc-ASC another radiotracer, ۹۹mTc-phytate (۹۹mTc-P) with different doses and injection methods were evaluated. Methods: Twenty-two patients, scheduled to undergo thyroidectomy for PTC, were injected for radio-guided SLN biopsy in the morning of operation in ۳ groups: intra tumoral injection of about ۱ mCi ۹۹mTc-P (group A; n=۵); peritumoral injection of less than ۳ mCi ۹۹mTc-ASC (group B; n=۶); and peritumoral injection of ۳ to ۵ mCi ۹۹mTc-ASC with application of massage (group C; n=۹). A patient refused to complete the study. A patient with follicular thyroid cancer was also excluded. No NLN was detected in the pre-operative ultra-sonographic examinations of all patients. Central neck dissection was done for all the participants. The presence of radio guided detected NLN and results of pathology were assessed. Results: In group A and B, no SLN was detected. NLNs were resected in ۴ patients in group A and B; ۲ of them involved by the tumor. In group C, ۶ out of ۹ patients (۶۶.۷%) had between ۱ to ۶ SLNs; the procedure failed to detect NLN in a patient in group C with surgically resected reactive NLN (failure rate ۱ out of ۷). Conclusion: The results underscored the significance of SLN radio guided biopsy in patients with PTC; the radiotracer, dose and method of injection may affect the detection rate.

کلیدواژه ها:

Sentinel Lymph Node Biopsy ، Thyroidectomy ، Papillary thyroid cancer

نویسندگان

Abbas Alibakhshi

Department of surgery, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Saeed Farzanehfar

Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mahya Zarei

Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Eftekhari

Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Maziar Motiee

Department of Otolaryngology–Head and Neck Surgery, Otolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Maryam Naseri

Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mehrshad Abbasi

Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

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