Effects of the diphenylheptane extract of Alpinia officinarum rhizomes on ethanol-induced gastric ulcers in mice
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 5
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 244
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شناسه ملی سند علمی:
JR_IJBMS-24-5_013
تاریخ نمایه سازی: 18 اردیبهشت 1400
چکیده مقاله:
Objective(s): Experimental studies have revealed that Alpinia officinarum Hance (Zingiberaceae) exhibits a gastrointestinal protective effect. The present study aimed to investigate the effects of diphenylheptanes (DPHs) extracted from A. officinarum rhizomes on ethanol-induced gastric ulcers in BALB/c mice.Materials and Methods: A total of ۶۰ female BALB/c mice were divided into six groups as follows: negative control, which received sodium carboxymethyl cellulose; positive control, which received ethanol; treatment control, which received ethanol+ranitidine; ethanol+high dose of DPHs; ethanol+medium dose of DPHs; ethanol+low dose of DPHs. Different doses of DPHs were administered orally once daily for seven consecutive days before the animals were subjected to ethanol-induced gastric ulcers.Results: Various doses of DPHs significantly reduced Gastric ulcers index when compared with the positive control. DPHs treatments and treatment control increased the activity of superoxide dismutase; decreased the levels of inflammatory mediators, malondialdehyde, motilin, and gastrin; decreased the activity of inducible nitric oxide synthase and cyclooxygenase-۲; and inhibited the expression of Toll-like receptor ۴, myeloid differentiation factor ۸۸, and nuclear factor-κB at the protein and mRNA levels. In addition, DPHs inhibited the expression of transient receptor potential vanilloid ۱, calcitonin gene-related peptide, and increased the expression of substance P at the protein and mRNA levels. Conclusion: The protective effect of DPHs extracted from A. officinarum rhizomes against ethanol-induced gastric damages in mice suggests that the extract can be used as an auxiliary supplement for the prevention and treatment of gastric ulcers.
کلیدواژه ها:
نویسندگان
Kaiwen Lin
School of Pharmacy, Hainan Medical University, Haikou, China
Huijuan Qu
School of Pharmacy, Hainan Medical University, Haikou, China
Yinfeng Tan
School of Pharmacy, Hainan Medical University, Haikou, China
Tang Deng
School of Pharmacy, Hainan Medical University, Haikou, China
Bingmiao Gao
School of Pharmacy, Hainan Medical University, Haikou, China
Na Wei
School of Pharmacy, Hainan Medical University, Haikou, China
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