Antiplasmodial activity of Anchomanes difformis aqueous leaf extract on Plasmodium berghei infected mice

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 220

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شناسه ملی سند علمی:

JR_TIPS-6-4_006

تاریخ نمایه سازی: 8 خرداد 1400

چکیده مقاله:

Challenges including treatment failure, cost, resistance, and adverse effects associated with antimalarial drugs have increased the use of medical plants as alternative treatment. Anchomanes difformis (A. difformis) is a multipurpose plant used traditionally for the treatment of a variety of ailments including malaria, but with a paucity of scientific evidence. This study assessed the antiplasmodial activity of A. difformis aqueous leaf extract (AEA) in Plasmodium berghei (P. berghei) infected mice. AEA (۱۰۰, ۲۰۰ and ۴۰۰ mg/kg) was orally administered to P. berghei infected mice in the curative, suppressive and prophylactic groups. The untreated parasitized control (UPC) and the positive control were administered orally with normal saline (۰.۲mL) and chloroquine (CQ) (۱۰mg/kg). After treatment, blood samples were analyzed for parasitamia level, hematological parameters and liver samples were evaluated for histology. Curative, suppressive and prophylactic studies showed that administered AEA decreased parasitamia levels and increased survival time in a dose-dependent fashion with significance at ۲۰۰ mg/kg (p

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نویسندگان

Bensandy Odeghe

Department of Biochemistry, Faculty of Science, Madonna University Nigeria

Elias Adikwu

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Nigeria

Frances John

Department of Biochemistry, Faculty of Science, Madonna University Nigeria

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  • Phillips RS. Current status of malaria and potential for control. ...
  • Greenwood B, Mutabingwa T. Malaria in ۲۰۰۲. Nature. ۲۰۰۲ Feb ...
  • Tabbabi A. Socio-economic Impact of Malaria in Africa. Acta Scie ...
  • White NJ. Antimalarial drug resistance ...
  • J Clin Invest. ۲۰۰۴;۱۱۳(۸):۱۰۸۴-۱۰۹۲. doi:۱۰.۱۱۷۲/JCI۲۱۶۸۲۵. Taek MM, Prajogo B, Agil ...
  • Plowman T. Folk uses of New World aroids. Econ Bot. ...
  • Tchiakpe L, Balansard G, Bernard P, Dalziel JM. The useful ...
  • Oyetayo VO. Comparative Studies of the Phytochemical and Antimicrobial Properties ...
  • J Pharm Toxicol. ۲۰۰۷;۲:۴۰۷-۱۰ ...
  • Dalziel JM (۱۹۳۷) The useful plants of West Tropical Africa. ...
  • Akah P, Njike HA. Some pharmacological effects of rhizome aqueous ...
  • Harborne J B. Phytochemical Methods. Chapman and Hall Ltd., London; ...
  • Trease G and Evans W C. Pharmacognosy. Bailliere Tindall, London, ...
  • Knight DJ, Mamalis P, Peters W. The antimalarial activity of ...
  • Lorke D. A new approach to practical acute toxicity testing. ...
  • Ryley JF, Peters W. The antimalarial activity of some quinolone ...
  • Peters, W. Rational methods in the search for antimalarial drugs. ...
  • Mahady GB. Medicinal plants for the prevention and treatment of ...
  • Ahmed H. A Anchomanes difformis: A Multipurpose Phytomedicine IOSR. J ...
  • Olanlokun JO, Babarinde CO and Olorunsogo O. O. Toxicity of ...
  • O'Neill PM, Barton VE, Ward SA. The molecular mechanism of ...
  • Iribhogbe OI, Agbaje EO, Oreagba IA, Aina O, Ota AD. ...
  • نمایش کامل مراجع