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NgR۱ pathway expression in cerebral ischemic Sprague-Dawley rats with cognitive impairment

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 6
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 207

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لینک ثابت به این مقاله:
https://civilica.com/doc/1225343

شناسه ملی سند علمی:

JR_IJBMS-24-6_008

تاریخ نمایه سازی: 17 خرداد 1400

چکیده مقاله:

Objective(s): This study aimed to determine the effect of ischemic occlusion duration and recovery time course on motor and cognitive function, identify optimal conditions for assessing cognitive function with minimal interference from motor deficits, and elucidate the underlying mechanism of axonal inhibitors.Materials and Methods: Sprague-Dawley (SD) rats were randomly allocated to the transient middle cerebral artery occlusion (tMCAO) ۶۰-min (tMCAO۶۰min), tMCAO۹۰min, tMCAO۱۲۰min, and sham groups. We conducted forelimb grip strength, two-way shuttle avoidance task, and novel object recognition task (NORT)tests at three time points (۱۴, ۲۱, and ۲۸ days). Expression of Nogo receptor-۱ (NgR۱), the endogenous antagonist lateral olfactory tract usher substance, ras homolog family member A (Rho-A), and RhoA-activated Rho kinase (ROCK) was examined in the ipsilateral thalamus.Results: There was no difference in grip strength between sham and tMCAO۹۰min rats at ۲۸ days. tMCAO۹۰min and tMCAO۱۲۰min rats showed lower discrimination indices in the NORT than sham rats on day ۲۸. Compared with that in sham rats, the active avoidance response rate was lower in tMCAO۹۰min rats on days ۱۴, ۲۱, and ۲۸ and in tMCAO۱۲۰min rats on days ۱۴ and ۲۱. Furthermore, ۵۰-۵۴% of rats in the tMCAO۹۰min group developed significant cognitive impairment on day ۲۸, and thalamic NgR۱, RhoA, and ROCK expression were greater in tMCAO۹۰min rats than in sham rats.Conclusion: Employing ۹۰-min tMCAO in SD rats and assessing cognitive function ۲۸ days post-stroke could minimize motor dysfunction effects in cognitive function assessments. Axonal inhibitor deregulation could be involved in poststroke cognitive impairment.

کلیدواژه ها:

Axonal inhibitor ، Cerebral ischemia ، Cognitive impairment ، Sprague-Dawley rats ، Stroke

نویسندگان

Ju Sun

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Ruifang Sun

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Chao Li

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Xun Luo

Kerry Rehabilitation Medicine Research Institute, Shenzhen ۵۱۸۰۴۸, Guangdong Province, China

Jiemei Chen

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Jiena Hong

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Yan Zeng

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

Qingmei Wang

Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, The Teaching Affiliate of Harvard Medical School,۹۶ ۱۳th Street, Charlestown, MA ۰۲۱۲۹

Hongmei Wen

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, ۶۰۰ Tianhe Road, Guangzhou ۵۱۰۶۳۰, Guangdong Province, China

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