Prediction of Pituitary Gland Complications by LKB and Log-Logistic Radiobiological Models in ۳D Conformal Radiation Therapy of Head and Neck Tumors

Sevda Shahbazi; Amir Ghasemi Jangjoo; Reza Eghdam Zamiri; Behnam Nasiri Motlagh; mohammad mohammadzadeh; murat okutan; Asghar Mesbahi

Prediction of Pituitary Gland Complications by LKB and Log-Logistic Radiobiological Models in ۳D Conformal Radiation Therapy of Head and Neck Tumors

محل انتشار: مجله فیزیک پزشکی ایران، دوره: 18، شماره: 3

سال انتشار: 1400

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 303

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https://civilica.com/doc/1225372

شناسه ملی سند علمی:

JR_IJMP-18-3_008

تاریخ نمایه سازی: 17 خرداد 1400

چکیده مقاله:

Introduction: The pituitary gland is frequently irradiated during radiation therapy of head and neck tumors which can influence the quality of life of the patients after radiation therapy. This study aimed to estimate the normal tissue complication probability (NTCP) for the pituitary gland in head and neck cancers using two radiobiological models. Material and Methods: ۵۳ patients including ۲۰ cases with nasopharyngeal cancer and ۳۳ cases with brain tumor were studied. The dosimetric properties of each plan including minimum, mean and maximum doses were extracted from the dose-volume histogram curve. For estimation of pituitary gland response for each patient, the BIOPLAN software was used to calculate NTCP by LKB model and Matlab software was applied to calculate NTCP by equivalent uniform dose (EUD) model. Models’ parameters including TD۵۰, , and‘a’ were extracted from a previous study of radiobiological modeling of pituitary gland response to radiation therapy. For statistical analysis, the T-test was used to compare two models. Results: The average mean doses of ۳۰.۴۲ and ۵۱.۲۹ (Gy) of the pituitary gland were obtained for nasopharyngeal and brain tumor patients, respectively. The average NTCPs of the pituitary gland for nasopharyngeal patients estimated by LKB and Log-logistic models were ۳.۸۴ and ۳.۹۱%, respectively. In brain tumors, the average NTCP was ۱۶.۳۳% for LKB and ۱۶.۴۱% for Log-logistic models. The results showed that the log-logistic and LKB models provided comparable results and no statistically significant difference (P-value< ۰.۰۵) was found between two models. Conclusion: The NTCP results indicated that the average NTCP of the pituitary gland for nasopharyngeal patients was approximately four times lower than that of brain tumors. Finally, implementation of follow up studies and modeling investigations are recommended for accurate estimation of pituitary gland complications following radiation therapy.

کلیدواژه ها:

Radiotherapy ، pituitary gland ، Radiobiological Models NTCP

نویسندگان

Sevda Shahbazi

Molecular Medicine Research Center, Institute of Biomedicine, Tabriz University of Medical Sciences, Tabriz, Iran

Amir Ghasemi Jangjoo