Imaging properties of Fe۳O۴@Au and Fe۳O۴@Bi hybrid nanocomposites as contrast agents in spectral X-ray computed tomography: A Monte Carlo simulation study
محل انتشار: مجله علوم نانو، دوره: 8، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 259
فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_NAMJ-8-3_007
تاریخ نمایه سازی: 19 تیر 1400
چکیده مقاله:
Objective(s): In this paper, we evaluated some imaging properties of Fe۳O۴@Au and Fe۳O۴@Bi hybrid nanocomposites as contrast agents in spectral CT. For this purpose, we simulated a spectral CT scanner with photon-counting detectors (PCDs) in ۶ energy bins by a Monte Carlo simulator.Materials and Methods: A cylindrical phantom was designed with a diameter of ۸ cm and a height of ۱۰ cm. Fe۳O۴@Au and Fe۳O۴@Bi hybrid nanocomposites were designed as a core-shell with a diameter of ۸۰ nm. Simulation results were utilized to reconstruct cross-sectional images through the filtered back-projection (FBP) algorithm in MATLAB software. Signal intensity and contrast to noise ratio (CNR) of tested contrast agents were calculated in spectral CT images. Results: The results indicated a comparable image quality for Fe۳O۴@Au and Fe۳O۴@Bi hybrid nanocomposites at different energy bins. However, in the energy range of ۸۰ to ۱۲۰ keV (bin ۴ and ۵), the difference in signal intensity and CNR between these two nanocomposites increased. The maximum signal intensity and CNR for Fe۳O۴@Au and Fe۳O۴@Bi were acquired at the highest concentration. The maximum signal intensity for Fe۳O۴@Au was ۱۴۴±۱۰ (HU) in the ۴th energy bin and for Fe۳O۴@Bi ۱۶۲±۱۹ (HU) in the ۵th energy bin. Besides, the maximum CNRs of ۷۴±۶ and ۶۷.۵±۹ for Fe۳O۴@Au in bin ۴, while for Fe۳O۴@Bi in bin ۵ were obtained respectively. Conclusion: Based on our results, Fe۳O۴@Au and Fe۳O۴@Bi hybrid nanocomposites have provided promising results as contrast agents in spectral CT. Fe۳O۴@Bi nanocomposites are recommended due to their lower price and availability.
کلیدواژه ها:
نویسندگان
Maryam Sadeghian
Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
Asghar Mesbahi
Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :