Sensitive Simultaneous Detection of Methyldopa and Hydrochlorothiazide on Ce۳+-NiO Hexagonal Nanoparticles-Modified Electrode

We applied GCE modified with Ce۳+-NiO hexagonal nanoparticles (Ce۳+-NiO HNPs) for preparing methyldopa electrochemical sensor. Electrochemical study of the modified electrode showed that within the optimal conditions of phosphate buffer solution (PBS) at a pH of ۷.۰ in CV, oxidation potency of methyldopa decline to ~۱۰۰ mV at the modified electrode in comparison with an unmodified GCE. The sensor exhibits a sensitive response to methyldopa in range between ۰.۱ and ۸۰.۰ μM with a limit of detection (LOD) equal to ۰.۰۳ μM. In addition, as sensing materials for simultaneously determine hydro-chlorothiazide and methyldopa, Ce۳+-NiO HNPs/GCE, exhibited high sensitivity. The defined and separated oxidation peaks of a mixture of methyldopa and hydrochlorothiazide were obtained with significant peak potential differences of ۳۹۰ V. The proposed electrochemical sensor was employed in analysis of both drugs in the real specimens.