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مقالات فارسیISIکنفرانسهاژورنالها

Recurrent Pregnancy Loss in a Subject with Heterozygote Factor V Leiden Mutation; a Case Report

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 2، شماره: 2
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 259

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لینک ثابت به این مقاله:
https://civilica.com/doc/1263156

شناسه ملی سند علمی:

JR_RBMB-2-2_007

تاریخ نمایه سازی: 10 شهریور 1400

چکیده مقاله:

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before ۲۰ weeks of gestation, which occurs in approximately ۵% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G۲۰۲۱۰A mutation, and methylenetetrahydrofolate reductase C۶۷۷T and A۱۲۹۸C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation.

کلیدواژه ها:

Hereditary thrombophilia ، Factor V Leiden mutation ، Recurrent pregnancy loss

نویسندگان

Reza Ebrahimzadeh-Vesal

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Roza Azam

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Arvin Ghazarian

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mogge Hajesmaeili

Department of Biology, Islamic Azad University of Parand, Tehran, Iran.

Najmeh Ranji

Department of Genetics, Faculty of Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran.

Mohammad Reza Ezzati

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mehrdad Sadri

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Ali Mohammadi

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Siamak Khavandi

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.