The Role of Helicobacter Pylori Eradication in the Treatment of Chronic Urticaria in Comparison with Classic Treatments

Introduction: Helicobacter pylori (H.pylori) is the most common chronic worldwide bacterial infection in humans in all of ages and  the majority of Chronic Urticarial patients also carry     H. Pylori. The purpose of the present study was to studied H. pylori eradication in the treatment of chronic urticaria in comparison with classic treatment on two treatment groups. Materials & Methods: participants were ۱۲۰ Chronic Urticaria patients with H. Pylori infected and positive Urease Breath Test (UBT) who refer to Quaem Hospital in Mashhad. Participants were randomly assigned two groups, control group received classic treatment of Urticaria (H۱ & H۲ Blockers) and investigation group was additional treatment by triple drug therapy (۲۰ mg of Robeprazole twice daily, ۵۰۰ mg of Clarithromycin twice daily, and ۱gr of Amoxicillin twice daily during ۱۴ days). Within one, three & six months after therapy symptoms were separately analyzed in two groups by using urticaria severity score. Results: As to the age factor, no significant difference was found (P-value: ۰.۸۶۳). However, the average age with regard to gender, was significantly higher in men (P-value: ۰.۰۰۶).The majority of patients who had been exposed to combination drug treatment, were significantly better cured than the group exposed to classic treatment lonely (P-value < ۰.۰۰۱) and many components of urticaria severity score showed better improvement respectively (P-value < ۰.۰۰۱). Conclusions: Addition of this treatment for eradication of Helicobacter pylori infection in patients with chronic urticaria, could be more effective than the classic H۱and H۲ blockers alone for resolution of symptoms.