The Toxic Components and the Clinical Uses of Snake Venom: A Review

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 145

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شناسه ملی سند علمی:

JR_PJMT-10-3_006

تاریخ نمایه سازی: 11 مهر 1400

چکیده مقاله:

Background: The venom of different snake species has a distinctive composition. This composition can be also affected by other factors such as age, sex, geographical, and seasonal variations. Generally, snake venom is composed of small molecules such as inorganic cations as well as enzymatic and non-enzymatic peptides, and proteins. Although snake bite poisoning is highly associated with death after systemic absorption of the venom, some studies report on snake venom’s composition, toxicodynamic, and potential therapeutic.Methods: Using electronic databases like ISI Web of Knowledge, PubMed, and Scopus, this review aims to point to some components of snake venom and how these components can be used for therapeutic and diagnostic purposes.Results: Snake venom was used for the treatment of different pathophysiological conditions in ancient times and is now being used in both modern and folk medicine. These have created the opportunity for scientists to discover new drugs that are more targeted to the site of action and have fewer adverse effects.Conclusion: Today, using special techniques of isolation and formulation, some purified snake venom components are being used for the treatment of acute and chronic conditions, while some others are under further clinical trials. This is due to their potential to produce antitumor, antimicrobial, analgesic, antiplatelet, hypotensive, and other activities.

نویسندگان

Sareh Dortaj

Pharmacist, Dubai Pharmacy College, Dubai Medical University, Dubai, United Arab Emirates

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  • Matsui T, Fujimura Y, Titani K. Snake venom proteases affecting ...
  • Chan YS, Cheung RCF, Xia L, Wong JH, Ng TB, ...
  • Vyas VK, Brahmbhatt K, Bhatt H, Parmar U. Therapeutic potential ...
  • Sanhajariya S, Duffull S, Isbister G. Pharmacokinetics of Snake Venom. ...
  • Chippaux J-P, Williams V, White J. Snake venom variability: methods ...
  • Meier Jür, Stocker K. Effects of Snake Venoms on Hemostasis. ...
  • Virmani S. CARDIAC INVOLVEMENT IN SNAKE BITE. Med J Armed ...
  • Devaraj T. Bleeding manifestations in snake bite. Southeast Asian J ...
  • Manjunatha Kini R. Excitement ahead: structure, function and mechanism of ...
  • G V, Geet A, Sonone S. Vasculotoxic snake bite induced ...
  • Dhananjaya BL, D’Souza CJM. The pharmacological role of nucleotidases in ...
  • Calvete JJ, Marcinkiewicz C, Monleón D, Esteve V, Celda B, ...
  • Yamazaki Y, Morita T. Structure and function of snake venom ...
  • Lu Q, Navdaev A, Clemetson JM, Clemetson KJ. Snake venom ...
  • Ali R, Mirza Z, Ashraf GMD, Kamal MA, Ansari SA, ...
  • Rajabi M, Mousa S. The Role of Angiogenesis in Cancer ...
  • Swenson S, Ramu S, Markland F. Anti-Angiogenesis and RGD-Containing Snake ...
  • Li L, Huang J, Lin Y. Snake Venoms in Cancer ...
  • Zinatizadeh MR, Zare Mirakabadi A, Kheirandish Zarandi P, Mirzaei HR, ...
  • Badari JC, Díaz-Roa A, Teixeira Rocha MM, Mendonça RZ, Silva ...
  • Rheubert JL, Meyer MF, Strobel RM, Pasternak MA, Charvat RA. ...
  • Mohamed Abd El-Aziz, Garcia Soares, Stockand. Snake Venoms in Drug ...
  • Fenard D, Lambeau G, Valentin E, Lefebvre J-C, Lazdunski M, ...
  • Shimizu JF, Pereira CM, Bittar C, Batista MN, Campos GRF, ...
  • Yamane ES, Bizerra FC, Oliveira EB, Moreira JT, Rajabi M, ...
  • Power I. An update on analgesics. Br J Anaesth. ۲۰۱۱ ...
  • Chu X-P, Xiong Z-G. Acid-Sensing Ion Channels in Pathological Conditions. ...
  • Zambelli V, Picolo G, Fernandes C, Fontes M, Cury Y. ...
  • Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, ...
  • Seneci L, Zdenek CN, Chowdhury A, Rodrigues CFB, Neri-Castro E, ...
  • Koh CY, Kini RM. From snake venom toxins to therapeutics ...
  • Hayashi MAF, Camargo ACM. The Bradykinin-potentiating peptides from venom gland ...
  • Joseph R, Pahari S, Hodgson W, Kini R. Hypotensive Agents ...
  • Yagami T, Yamamoto Y, Kohma H, Nakamura T, Takasu N, ...
  • Fuster V, Stein B, Ambrose JA, Badimon L, Badimon JJ, ...
  • Lazarovici P, Marcinkiewicz C, Lelkes PI. From Snake Venom’s Disintegrins ...
  • Hynes RO. Integrins. Cell. ۲۰۰۲ Sep;۱۱۰(۶):۶۷۳–۸۷ ...
  • Schwartz MA, Ginsberg MH. Networks and crosstalk: integrin signalling spreads. ...
  • Selistre-de-Araujo HS, Pontes CLS, Montenegro CF, Martin ACBM. Snake Venom ...
  • Shattil SJ, Kim C, Ginsberg MH. The final steps of ...
  • Waheed H, Moin SF, Choudhary MI. Snake Venom: From Deadly ...
  • Munawar A, Ali S, Akrem A, Betzel C. Snake Venom ...
  • Mohammadpourdounighi N, Behfar A, Ezabadi A, Zolfagharian H, Heydari M. ...
  • نمایش کامل مراجع