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مقالات فارسیISIکنفرانسهاژورنالها

Transient receptor potential V۱ modulates neuroinflammation in Parkinson’s disease dementia: Molecular implications for electroacupuncture and rivastigmine

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 10
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 168

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لینک ثابت به این مقاله:
https://civilica.com/doc/1280663

شناسه ملی سند علمی:

JR_IJBMS-24-10_003

تاریخ نمایه سازی: 11 مهر 1400

چکیده مقاله:

Objective(s): Parkinson’s disease (PD) is a common progressive neurodegeneration disease. Its incidence increases with age and affects about ۱% of people over ۶۰. Incidentally, transient receptor potential V۱ (TRPV۱) and its relation with neuroinflammation in mouse brain has been widely reported.Materials and Methods: We used ۶-hydroxydopamine (۶-OHDA) to induce PDD in mice. We then used the Morris water maze and Bio-Plex to test learning and inflammatory mediators in mouse plasma. Western blotting and immunostaining were used to examine TRPV۱ pathway in the hippocampus and medial prefrontal cortex (mPFC). Results: On acquisition days ۳ (Control = ۴.۴۰ ± ۰.۸ sec, PDD = ۹.۸۲ ± ۱.۵۲ sec, EA = ۵.۰۴ ± ۰.۵۸ sec, Riva = ۴.۷۵ ± ۰.۸۷ sec; P=۰.۰۰۱) and ۴, reversal learning days ۱, ۲, ۳ (Control = ۲.۸۶ ± ۰.۴۶ sec, PDD = ۹.۸۰ ± ۱.۸۳ sec, EA = ۴.۶ ± ۰.۸۲ sec, Riva = ۴.۶ ± ۱.۰۳ sec; P=۰.۰۰۱) and ۴, PDD mice showed significantly longer escape latency than the other three groups. Results showed that several cytokines were up-regulated in PDD mice and reversed by EA and rivastigmine. TRPV۱ and downstream molecules were up-regulated in PDD mice and further reversed by EA and rivastigmine. Interestingly, α۷ nicotinic receptors and parvalbumin levels in both the hippocampus and prefrontal cortex increased in EA-treated mice, but not in rivastigmine-treated mice.Conclusion: Our results showed that TRPV۱ played a role in the modulation of neuroinflammation of PDD, and could potentially be a new target for treatment.

کلیدواژه ها:

Electroacupuncture ، Hippocampus ، Neuroinflammation ، Parkinson’s disease dementia ، Rivastigmine ، Transient receptor potential V۱

نویسندگان

Sheng-Ta Tsai

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Tzu-Hsuan Wei

Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan

Yu-Wan Yang

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Ming-Kuei Lu

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Shao San

Department of Psychiatry, Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan, Taiwan

Chon-Haw Tsai

Department of Neurology, China Medical University Hospital, Taichung, Taiwan

Yi-Wen Lin

Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan

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