Detrimental effects of cerium oxide nanoparticles on testis, sperm parameters quality, and in vitro fertilization in mice: An experimental study
محل انتشار: مجله طب تولید مثل ایران، دوره: 19، شماره: 9
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 193
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شناسه ملی سند علمی:
JR_IJRM-19-9_005
تاریخ نمایه سازی: 18 مهر 1400
چکیده مقاله:
Background: Cerium oxide nanoparticles (CeO۲ NPs) as an important nanomaterial have a wide range of applications in many fields and human beings’ exposure to this nanomaterial is unavoidable. The effects of CeO۲ NPs on the male reproductive system are controversial.
Objective: To determine the effects of the administration of CeO۲ NPs on the testis tissue, sperm parameters, and in vitro fertilization (IVF) in mice.
Materials and Methods: Twenty-four male mice were divided into three groups (n = ۸/each): one control and two experimental groups receiving CeO۲ NPs at doses of ۵۰ and ۱۰۰ mg/kg body weight, respectively, for ۳۵ days. At the end of the experiment, the diameter of seminiferous tubules (SNTs), epithelial height of SNTs, spermiogenesis index in testes, sperm parameters (count, motility, viability, and morphology), sperm chromatin condensation, DNA integrity, and IVF assays were analyzed.
Results: Histological results showed that the tubular diameter, the epithelial height of the SNTs, and the spermiogenesis index were significantly decreased in the experimental groups receiving CeO۲ NPs. All sperm parameters in the experimental groups were significantly reduced and, additionally, the percentages of immature sperms and sperms with DNA damage were significantly increased in groups treated with CeO۲ NPs compared to the control. Furthermore, the rates of IVF and in vitro embryo development were decreased.
Conclusion: Collectively, the current study showed that oral administration of CeO۲ NPs in mice had detrimental effects on the male reproductive system through inducing testicular tissue alterations, decreasing sperm parameters quality, and also diminishing the IVF rate and in vitro embryonic development.
کلیدواژه ها:
Cerium oxide ، Testis ، Sperm ، Fertilization ، Mice. ، نانوذرات اکسید سریوم ، بیضه ، اسپرم ، لقاح ، موش.
نویسندگان
Elnaz Hosseinalipour
Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Mojtaba Karimipour
Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Abbas Ahmadi
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
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