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مقالات فارسیISIکنفرانسهاژورنالها

Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 10
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 145

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295213

شناسه ملی سند علمی:

JR_IJBMS-21-10_005

تاریخ نمایه سازی: 27 مهر 1400

چکیده مقاله:

Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (۷۲ μg/kg, ۹۶ μg/kg and ۱۲۰ μg/kg) after CLP. The prothrombin time (PT), activated partial thromboplastin time (APTT) was measured, respectively, the level of malondialdehyde (MDA), tissue factor (TF), activated coagulation factor VIIa and Xa, p-selectin were detected, the histology structure of vascular was observed, the expressions of Caspase ۹, Caspase ۳, Bax, Bcl-۲ and vWF in vascular were measured.Results: The results demonstrated that adiponectin treatment lengthened PT and APTT, reduced the expression of MDA, TF, activated coagulation factor VIIa, Xa and p-selectin in plasma of septic rats. Additionally, adiponectin treatment alleviated endothelial cell apoptosis and oxidative stress, down-regulated the levels of Caspase ۳, Caspase ۹, Bax, Bcl-۲ and vWF in vascular.Conclusion: These findings suggest that adiponectin treatment might be a promising therapeutic strategy for relieving septic endothelial cell injury and coagulation dysfunction via inhibiting endothelial cell apoptosis in septic rats.

کلیدواژه ها:

Adiponectin ، Apoptosis ، Endothelial cells ، Oxidative stress ، Rats ، Sepsis ، Thrombophilia

نویسندگان

Yun Hou

Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China

Xi-Feng Wang

Department of Critical Care Medicine, Yu Huang Ding Hospital, Qingdao University, Yantai, P R China

Zhi-Qiang Lang

Department of Pathology, Yu Huang Ding Hospital, Qingdao University, Yan Tai, P R China

Wei Zhao

Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China

Yinchuan Jin

Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China

Hong-Qin Zhang

Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China

Lian-Shuang Zhang

Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China

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