ورود
مقالات فارسیISIکنفرانسهاژورنالها

Fetal microchimerism in mouse caerulein-induced pancreatitis model

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 9
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 108

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295227

شناسه ملی سند علمی:

JR_IJBMS-21-9_004

تاریخ نمایه سازی: 27 مهر 1400

چکیده مقاله:

Objective(s): Fetal microchimerism is the persistence of allogeneic cell population that transfer from the fetus to the mother. The aim of this study was to evaluate the presence of fetal microchimerism in the pancreas of the mouse with acute pancreatitis (AP).Materials and Methods: In this experimental study, female wild-type mice were mated with male EGFP+. AP model was obtained by injection of caerulein two days after delivery. Sixty mice were divided into ۳ groups:  the virgin pancreatitis-induced animals, pregnant pancreatitis-induced animals mated with transgenic EGFP mice, and pregnant sham animals. To prove pancreatitis induction, the blood amylase and lipase were assessed; and pancreas was removed from a subpopulation of each group for histopathological examinations after ۶ hr. The remaining mice were kept for ۳ weeks and histopathological exanimation, immunohistochemistry, and PCR were performed.Results: EGFP+ cells were found in acini and around the blood vessels in the pancreas of pregnant pancreatitis-induced animals. They differentiated to acinar, adipocyte-like, and mesenchymal-like cells. PCR showed that ۲۰% of the pregnant pancreatitis-induced animals were EGFP+. The histopathological study showed improvement in pancreatitis scores in the mice with history of pregnancy. Conclusion: It seems that pregnancy has a beneficial impact on caerulein-induced pancreatitis and improves the pancreatitis score in mouse.

کلیدواژه ها:

Acute pancreatitis ، Caerulein ، Chimerism ، Enhanced green fluorescent protein ، Mice ، pregnancy

نویسندگان

Zahra Vojdani

Laboratory for Stem Cell Research, Anatomy Department, Medical school, Shiraz University of Medical Sciences, Shiraz, Iran

Jafar Bagheri

Laboratory for Stem Cell Research, Anatomy Department, Medical school, Shiraz University of Medical Sciences, Shiraz, Iran

Tahereh Talaei-Khozani

Laboratory for Stem Cell Research, Anatomy Department, Medical school, Shiraz University of Medical Sciences, Shiraz, Iran

Negar Azarpira

Transplantation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mahin Salmannjad

Laboratory for Stem Cell Research, Anatomy Department, Medical school, Shiraz University of Medical Sciences, Shiraz, Iran

Ali Farokhi

Royan Institute for Stem Cell Biology and Technology, ACECR Department of Stem Cell and Developmental Biology, Cell Science Research Center, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Nelson JL. The otherness of self: microchimerism in health and ...
  • Gill RM, Lee TH, Utter GH, Reed WF, Wen L, ...
  • Boyon C, Collinet P, Boulanger L, Rubod C, Lucot JP, ...
  • Knippen MA. Microchimerism: Sharing Genes in Illness and in Health. ...
  • Schnitzler M, Fisch P. A role for microchimerism in obesity ...
  • Fugazzola L, Cirello V, Beck-Peccoz P. Microchimerism and endocrine disorders. ...
  • Sunami R, Komuro M, Tagaya H, Hirata S. Migration of ...
  • Dawe GS, Tan XW, Xiao ZC. Cell migration from baby ...
  • Klonisch T, Drouin R. Fetal–maternal exchange of multipotent stem/progenitor cells: ...
  • Khosrotehrani K, Johnson KL, Cha DH, Salomon RN, Bianchi DW. ...
  • Lee ES, Bou-Gharios G, Seppanen E, Khosrotehrani K, Fisk NM. ...
  • Khosrotehrani K, Bianchi DW. Multi-lineage potential of fetal cells in ...
  • Pritchard S, Peter I, Johnson KL, Bianchi DW. The natural ...
  • Fujiki Y, Tao K, Bianchi DW, Giel-Moloney M, Leiter AB, ...
  • Khosrotehrani K, Johnson KL, Lau J, Dupuy A, Cha DH, ...
  • O’Donoghue K, Chan J, de la Fuente J, Kennea N, ...
  • Wang Y, Iwatani H, Ito T, Horimoto N, Yamato M, ...
  • Bayes-Genis A, Bellosillo B, de la Calle O, Salido M, ...
  • Santos MA, O’Donoghue K, Wyatt-Ashmead J, Fisk NM. Fetal cells ...
  • Zhang G, Zhao Y, Li XM, Kong J. Fetal cell ...
  • Nelson JL. Microchimerism and scleroderma. Curr Rheumatol Rep ۱۹۹۹; ۱:۱۵-۲۱ ...
  • Lambert N. Microchimeric cells: guardians or actors of immunity in ...
  • Ye Y, Berendine VZ, Hellmich C, Gillespie KM. Microchimerism: covert ...
  • VanZyl B, Gillespie KM. Microchimerism in type ۱ diabetes. Curr ...
  • Nguyen Huu S, Oster M, Avril MF, Boitier F, Mortier ...
  • Johnson KL, Samura O, Nelson JL, McDonnell M d WM, ...
  • Sunami R, Komuro M, Yuminamochi T, Hoshi K, Hirata S. ...
  • Tan XW, Liao H, Sun L, Okabe M, Xiao ZC, ...
  • Carvalho KM, Morais TC, de Melo TS, de Castro Brito ...
  • Raraty MG, Murphy JA, Mcloughlin E, Smith D, Criddle D, ...
  • Lerch MM, Gorelick FS. Models of acute and chronic pancreatitis. ...
  • Lerch MM Gorelick FS. Models of acute and chronic pancreatitis. ...
  • Warzecha Z, Sendur P, Ceranowicz P, Dembiński M, Cieszkowski J, ...
  • Welsch T, Endlich K, Giese T, Büchler MW, Schmidt J. ...
  • Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, ...
  • Johnson KL, Nelson JL, Furst DE, McSweeney PA, Roberts DJ, ...
  • Ayatollahi M, Talaei-Khozani T, Razmkhah M. Growth suppression effect of ...
  • Park CW, Kim KS, Bae S, Son HK, Myung PK, ...
  • Nassar D, Khosrotehrani K, Aractingi S. Fetal microchimerism in skin ...
  • Artlett CM, Rasheed M, Russo-Stieglitz KE, Sawaya HH, Jimenez SA. ...
  • Florim GM, Caldas HC, de Melo JC, Baptista MA, Fernandes ...
  • da Silva Florim GM, Caldas HC, Pavarino EC, Bertollo EM, ...
  • Bustos ML, Frías S, Ramos S, Estrada A, Arreola JL, ...
    • نمایش کامل مراجع