ADAM۳۳ gene polymorphisms in Southwestern Iranian patients with asthma
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 8
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 139
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شناسه ملی سند علمی:
JR_IJBMS-21-8_007
تاریخ نمایه سازی: 27 مهر 1400
چکیده مقاله:
Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than ۱۰۰ candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM۳۳. However, the relationship between ADAM۳۳ gene polymorphisms and asthma is controversial. The aim of this study was to investigate the association between four ADAM۳۳ gene SNPs and susceptibility to asthma in patients from southwestern Iran. Materials and Methods: ADAM۳۳ gene polymorphisms at positions T+۱ (rs۲۲۸۰۰۹۱), T۱ (rs۳۹۱۸۳۹۶), S۱ (rs۲۲۸۰۰۸۹), and F+۱ (rs۵۱۱۸۹۸) were examined in ۱۵۰ patients with asthma and ۱۴۹ age- and sex-matched healthy controls with a PCR-RFLP method. Results: There were no differences between patients and controls in allelic or genotype frequencies of ADAM۳۳ SNPs. We found no associations between allelic or genotype distribution of the SNPs and spirometry indices, concomitant involvement of other allergic diseases, or exposure to cigarette smoke. In contrast to H۴ haplotype, which appeared to be protective against asthma, inheritance of H۲ and H۳ haplotypes increased the risk of asthma up to ۲–۳ folds. Conclusion: ADAM۳۳ gene polymorphisms appear to play a partial role in asthma susceptibility, investigation of expression changes in this gene in response to environmental factors or the local formation of a soluble form of the molecule in the lung can be helpful to elucidate the impact of this molecule in the induction of asthma.
نویسندگان
Shirin Farjadnia
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
Mozhgan Moghtaderi
Allergy Clinic of Ali-Asghar Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Bent-Alhoda Hoseini-Pouya
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
Azin Ebrahimpour
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
Mahboubeh Nasiri
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
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