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مقالات فارسیISIکنفرانسهاژورنالها

Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB /p۳۸ pathway

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 3
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 91

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1295333

شناسه ملی سند علمی:

JR_IJBMS-21-3_003

تاریخ نمایه سازی: 27 مهر 1400

چکیده مقاله:

Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p۳۸ mitogen-activated protein kinase (p۳۸ MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammation and remodeling in monocrotaline (MCT) induced PAH in rats. Materials and Methods: An in vivo model of PAH induced by MCT was employed. Statistical analyses were assessed bydone using one-way analysis of variance (ANOVA) or Fisher's LSD test for multiple comparisons. Results: Four weeks of CIHH exposure following MCT injection resulted in significant reduction of mean pulmonary artery pressure (mPAP) level and improvement of right ventricular hypertrophy (RVH). Morphometric analyses showed decreased wall thickness of pulmonary arterioles in MCT+CIHH treated rats. These findings are consistent with the decrease in Ki-۶۷ immunostaining. Following CIHH treatments, apoptotic analysis showed a consistent decrease in T lymphocytes together with lower levels of CD۴+ T cell subset as measured in spleen and blood samples. Furthermore, CIHH treatment resulted in markedly reduced expression of TNF-α and IL-۶ via the inhibition of NF-κB and p۳۸ MAPK activity in rat lungs. Conclusion: Altogether, these results provide new evidence relating to the mode of action of CIHH in the prevention of PAH induced by MCT.

کلیدواژه ها:

Chronic intermittent ، hypobaric hypoxia Inflammation Monocrotaline NFκB Pulmonary arterial ، hypertension p۳۸ MAPK

نویسندگان

Lei Gao

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Jun Liu

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Yongmei Hao

Department of Endocrinology, the Second Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۰۰, China

Zengren Zhao

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Huilian Tan

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Jie Zhang

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Ning Meng

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Qinghou Zheng

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Zhen Wang

Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, ۰۵۰۰۳۱, China

Yi Zhang

Department of Physiology, Foundation Medicine School of Hebei Medical University, Shijiazhuang, ۰۵۰۰۱۷, China

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