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مقالات فارسیISIکنفرانسهاژورنالها

Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 2
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 127

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295374

شناسه ملی سند علمی:

JR_IJBMS-21-2_005

تاریخ نمایه سازی: 27 مهر 1400

چکیده مقاله:

Objective(s): Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods: In this study four groups (n = ۶–۸) of rats were used as follows: Sham, CCI, CCI + minocycline (MIN) ۱۰ mg/Kg (IP) and CCI + MIN ۳۰ mg/Kg (IP). On days ۳, ۷, ۱۴, and ۲۱ post-surgery hot-plate, acetone, and von Frey tests were carried out. Finally, Motor Nerve Conduction Velocity Evaluation (MNCV) assessment was performed and spinal cords were harvested in order to measure tissue concentrations of TNF_α, IL-۱β, Glutathione peroxidase (GPx), Superoxide dismutase (SOD) and Malondialdehyde (MDA). Extent of perineural inflammation and damage around the sciatic nerve was histopathologically evaluated. Results: Our results demonstrated that CCI significantly caused hyperalgesia and allodynia twenty-one days after CCI. MIN attenuated heat hyperalgesia, cold and mechanical allodynia and MNCV in animals. MIN also decreased the levels of TNF_α and IL-۱β. Antioxidative enzymes (SOD, MDA, and GPx) were restored following MIN treatment. Our findings showed that MIN decreased perineural inflammation around the sciatic nerve. According to the results, the neuropathic pain reduced in the CCI hyperalgesia model using ۳۰ mg/kg of minocycline. Conclusion: It is suggested that antinociceptive effects of minocycline might be mediated through the inhibition of inflammatory response and attenuation of oxidative stress.

کلیدواژه ها:

Chronic constriction- ، Injury ، Inflammatory response ، Minocycline ، Neuropathic pain ، Oxidative stress ، Rat

نویسندگان

Abolfazl Abbaszadeh

Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran

Saeideh Darabi

۲Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Amin Hasanvand

۲Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Hossein Amini-Khoyi

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Amir Abbasnezhad

Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran

Razieh Choghakhori

Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran

Asghar Aaliehpour

Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran

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  • Zhuo M. Neuronal mechanism for neuropathic pain. Mol Pain ۲۰۰۷;۳:۱۴ ...
  • Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, ...
  • De Jongh RF, Vissers KC, Meert TF, Booij LH, De ...
  • Saika F, Kiguchi N, Kobayashi Y, Kishioka S. Peripheral alpha۴beta۲ ...
  • Ma W, Quirion R. Does COX۲-dependent PGE۲ play a role ...
  • Naik AK, Tandan SK, Dudhgaonkar SP, Jadhav SH, Kataria M, ...
  • Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, ...
  • Kraus RL, Pasieczny R, Lariosa-Willingham K, Turner MS, Jiang A, ...
  • Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity ...
  • Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, ...
  • Mishra MK, Ghosh D, Duseja R, Basu A. Antioxidant potential ...
  • Fan LW, Pang Y, Lin S, Tien LT, Ma T, ...
  • Heo K, Cho YJ, Cho KJ, Kim HW, Kim HJ, ...
  • Stirling DP, Koochesfahani KM, Steeves JD, Tetzlaff W. Minocycline as ...
  • Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, ...
  • Chen W, Zhao M, Zhao S, Lu Q, Ni L, ...
  • Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, ...
  • Wang X, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, ...
  • Baumans V, Van Loo PL. How to improve housing conditions ...
  • Hamidi GA, Jafari-Sabet M, Abed A, Mesdaghinia A, Mahlooji M, ...
  • Hajhashemi V, Minaiyan M, Banafshe HR, Mesdaghinia A, Abed A. ...
  • Padi SS, Kulkarni SK. Minocycline prevents the development of neuropathic ...
  • Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that ...
  • Jain V, Jaggi AS, Singh N. Ameliorative potential of rosiglitazone ...
  • Kukkar A, Singh N, Jaggi AS. Neuropathic pain-attenuating potential of ...
  • Abed A, Hajhashemi V, Banafshe HR, Minaiyan M, Mesdaghinia A. ...
  • Wang H, Li X, Shan L, Zhu J, Chen R, ...
  • Saeedi Saravi SS, Hasanvand A, Shahkarami K, Dehpour AR. The ...
  • Hasanvand A, Abbaszadeh A, Darabi S, Nazari A, Gholami M, ...
  • Brummett CM, Padda AK, Amodeo FS, Welch KB, Lydic R. ...
  • Jaggi AS, Jain V, Singh N. Animal models of neuropathic ...
  • Pabreja K, Dua K, Sharma S, Padi SS, Kulkarni SK. ...
  • Biscaro B, Lindvall O, Tesco G, Ekdahl CT, Nitsch RM. ...
  • Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, ...
  • Peng B, Xiao J, Wang K, So KF, Tipoe GL, ...
  • El-Shimy IA, Heikal OA, Hamdi N. Minocycline attenuates Abeta oligomers-induced ...
  • Nikodemova M, Duncan ID, Watters JJ. Minocycline exerts inhibitory effects ...
  • Choi Y, Kim HS, Shin KY, Kim EM, Kim M, ...
  • Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, ...
  • Wang J, Wei Q, Wang CY, Hill WD, Hess DC, ...
  • Scarabelli TM, Stephanou A, Pasini E, Gitti G, Townsend P, ...
  • Zhu F, Zheng Y, Liu Y, Zhang X, Zhao J. ...
  • Cukras CA, Petrou P, Chew EY, Meyerle CB, Wong WT. ...
  • Bhatt LK, Veeranjaneyulu A. Minocycline with aspirin: a therapeutic approach ...
  • Shubayev VI, Myers RR. Upregulation and interaction of TNFalpha and ...
  • Covey WC, Ignatowski TA, Knight PR, Spengler RN. Brain-derived TNFalpha: ...
  • Lee H-L, Lee K-M, Son S-J, Hwang S-H, Cho H-J. ...
  • Lee KM, Jeon SM, Cho HJ. Tumor necrosis factor receptor ...
  • Siniscalco D, Fuccio C, Giordano C, Ferraraccio F, Palazzo E, ...
  • Kim HY, Wang J, Lu Y, Chung JM, Chung K. ...
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