ورود
مقالات فارسیISIکنفرانسهاژورنالها

Protective effect of metformin on D-galactose-induced aging model in mice

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 193

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295389

شناسه ملی سند علمی:

JR_IJBMS-21-1_004

تاریخ نمایه سازی: 27 مهر 1400

چکیده مقاله:

Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (۱ and ۱۰ mg/kg/p.o.), was administrated daily in D-gal-received (۵۰۰ mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.

کلیدواژه ها:

Aging ، D-galactose ، Metformin ، Mouse ، Oxidative stress

نویسندگان

Iman Fatemi

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Amin khaluoi

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ayat Kaeidi

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ali Shamsizadeh

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Sara Heydari

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Allahtavakoli

Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Shin KR, Kim MY, Kim YH. Study on the lived ...
  • Kennedy BK, Pennypacker JK. Drugs that modulate aging: the promising ...
  • Forster MJ, Dubey A, Dawson KM, Stutts WA, Lal H, ...
  • Pak JW, Herbst A, Bua E, Gokey N, McKenzie D, ...
  • van Velzen LS, Wijdeveld M, Black CN, van Tol MJ, ...
  • Joseph J, Cole G, Head E, Ingram D. Nutrition, brain ...
  • Xu Y, Wu T, Jin Y, Fu Z. Effects of ...
  • Wei H, Li L, Song Q, Ai H, Chu J, ...
  • Kothari V, Galdo JA, Mathews ST. Hypoglycemic agents and potential ...
  • Łabuzek K, Suchy D, Gabryel B, Bielecka A, Liber S, ...
  • Markowicz-Piasecka M, Sikora J, Szydlowska A, Skupien A, Mikiciuk-Olasik E, ...
  • Zhao R-r, Xu X-c, Xu F, Zhang W-l, Zhang W-l, ...
  • Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, ...
  • McCarty MF. Chronic activation of AMP-activated kinase as a strategy ...
  • Kaviani E, Rahmani M, Kaeidi A, Shamsizadeh A, Allahtavakoli M, ...
  • Pellow S, Chopin P, File SE, Briley M. Validation of ...
  • Fatemi I, Shamsizadeh A, Ayoobi F, Taghipour Z, Sanati MH, ...
  • Roohbakhsh A, Shamsizadeh A, Arababadi MK, Ayoobi F, Fatemi I, ...
  • Ayoobi F, Fatemi I, Roohbakhsh A, Shamsizadeh A. Tactile learning ...
  • Zamanian M, Hajizadeh MR, Nadimi AE, Shamsizadeh A, Allahtavakoli M. ...
  • Zhang XL, An LJ, Bao YM, Wang JY, Jiang B. ...
  • Pourmemar E, Majdi A, Haramshahi M, Talebi M, Karimi P, ...
  • Ge XH, Zhu GJ, Geng DQ, Zhang HZ, He JM, ...
  • Oliveira WH, Nunes AK, Franca ME, Santos LA, Los DB, ...
  • Ashabi G, Sarkaki A, Khodagholi F, Zareh Shahamati S, Goudarzvand ...
  • Thangthaeng N, Rutledge M, Wong JM, Vann PH, Forster MJ, ...
  • Takeda M, Takahashi M, Matsumoto S. Inflammation enhanced brain-derived neurotrophic ...
  • Kumar A, Pareek V, Faiq MA, Kumar P, Raza K, ...
  • Ghadernezhad N, Khalaj L, Pazoki-Toroudi H, Mirmasoumi M, Ashabi G. ...
  • Smieszek A, Strek Z, Kornicka K, Grzesiak J, Weiss C, ...
  • Yang X, Ding H, Qin Z, Zhang C, Qi S, ...
  • El-Lakkany NM, Seif El-Din SH, Sabra AA, Hammam OA, Ebeid ...
  • Mansour HH, El Kiki SM, Galal SM. Metformin and low ...
  • Garabadu D, Krishnamurthy S. Diazepam potentiates the antidiabetic, antistress and ...
  • Therrien Z, Hunsley J. Assessment of anxiety in older adults: ...
  • Haider S, Liaquat L, Shahzad S, Sadir S, Madiha S, ...
  • Damian JP, Acosta V, Da Cuna M, Ramirez I, Oddone ...
  • Sarkaki A, Farbood Y, Badavi M, Khalaj L, Khodagholi F, ...
  • Chang L, Liu X, Liu J, Li H, Yang Y, ...
  • Boengler K, Kosiol M, Mayr M, Schulz R, Rohrbach S. ...
  • Sun D, Yang F. Metformin improves cardiac function in mice ...
  • Izzo A, Nitti M, Mollo N, Paladino S, Procaccini C, ...
    • نمایش کامل مراجع