Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 12
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 130
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-20-12_001
تاریخ نمایه سازی: 28 مهر 1400
چکیده مقاله:
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L۱.۱, L۱.۲, Major vault protein (MVP), contactin-۲ and High mobility group box۱ (HMGB۱) had positive promoting effects on axonal re-growth while Ptena had an inhibitory effect. Neurogenesis is stimulated by Wnt/ß-catenin signaling as well as HMGB۱, but inhibited by Notch signaling. Glial cells proliferate in response to fibroblast growth factor (fgf) signaling and Lysophosphatidic acid (LPA). Furthermore, fgf signaling pathway causes glia bridge formation in favor of axonal regeneration. LPA and HMGB۱ in acute phase stimulate inflammatory responses around injury and suppress regeneration. LPA also induces microglia activation and neuronal death in addition to glia cell proliferation, but prevents neurite sprouting. Conclusion: This study provides a comprehensive review of the known molecules and mechanisms in the current literature involved in the spinal cord injury (SCI) regeneration in zebrafish, in a time course manner. A better understanding of the whole determining mechanisms for the SCI regeneration should be considered as a main goal for future studies.
کلیدواژه ها:
نویسندگان
Zeynab Noorimotlagh
Medical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Mahla Babaie
Medical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Mahdi Safdarian
Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Tahereh Ghadiri
Tabriz University of Medical Sciences, Tabriz, Iran
Vafa Rahimi-Movaghar
Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, ۱۱۳۶۵-۳۸۷۶, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :