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Berberis integerrima ameliorates insulin resistance in high- fructose-fed insulin-resistant rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 10
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 187

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295647

شناسه ملی سند علمی:

JR_IJBMS-20-10_004

تاریخ نمایه سازی: 28 مهر 1400

چکیده مقاله:

Objective(s): This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for ۸ weeks. After the first six weeks, the animals were treated with B. integerrima extract or pioglitazone for two weeks. Insulin and adiponectin levels were measured by ELISA. Additionally, Insulin resistance was calculated using a Homeostasis Model Assessment of Insulin resistance (HOMA-IR). The plasma free fatty acid (FFA) profile was obtained by gas chromatography. PPARγ and GLUT۴ gene expression were assessed by real-time polymerase chain reaction (PCR) and western-blotting. Results: Comparing the B. integerrima treated group with the control group, weight gain (P=۰.۰۰۹) and levels of insulin (P=۰.۰۰۱), blood glucose (P<۰.۰۰۰۱), and HOMA-IR (P<۰.۰۰۰۱) were significantly reduced. Additionally, the adiponectin concentration was significantly increased (P<۰.۰۰۰۱). Among the FFA fractions, the mean concentration of palmitoleic acid and stearic acid in the B. integerrima group were significantly higher than the control group (P<۰.۰۰۰۱ and P=۰.۰۰۵, respectively). However, there was no significant difference at the mRNA and protein level of GLUT۴ and PPAR-γ between B. integerrima treated group and control group. Conclusion: The study findings revealed that B. integerrima might be a protective candidate against Type ۲ diabetes/insulin resistance through direct insulin-like effect and an increase in adiponectin levels. However, the mechanism of B. integerrima was independent of GLUT۴ and PPARγ.

کلیدواژه ها:

Adiponectin ، Diabetes ، Free fatty acids ، insulin resistance ، metabolic syndrome

نویسندگان

Hossein Fallah

Department of Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Hamed Akbari

Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Moslem Abolhassani

Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abbas Mohammadi

Department of Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Ahmad Gholamhosseinian

Department of Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

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