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The hedgehog/Gli-۱ signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT۱۱۶ cells

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 11
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137

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این مقاله در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295816

شناسه ملی سند علمی:

JR_IJBMS-19-11_004

تاریخ نمایه سازی: 30 مهر 1400

چکیده مقاله:

Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT۱۱۶ cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-۱ signaling pathways. Materials and Methods: We chose the appropriate time and concentration of recombinant human Sonic hedgehog (Shh) stimulation by cell viability. The proportion of cell apoptosis was detected by flow cytometry; HCT۱۱۶ cell migration was measured by scratch test; the expression of Ptch, Smo, and Gli-۱ was measured by Western blot analysis. Results: Shh signaling increased HCT۱۱۶ cell viability and migration, inhibited cell apoptosis, and upregulated the expression of Ptch, Smo, and Gli-۱. Resveratrol obviously inhibited HCT۱۱۶ cell viability and migration, promoted cell apoptosis, and suppressed the protein of Ptch, Smo, and Gli-۱. Furthermore, the effects of resveratrol and Shh on human colorectal cancer HCT۱۱۶ cells were in a dose- and time-dependent manner. Conclusion: The inhibitory effect of resveratrol on HCT۱۱۶ cells may be mediated by hedgehog/gli-۱ signaling pathways.

کلیدواژه ها:

Colorectal cancer ، Hedgehog/gli-۱ ، Resveratrol ، Signaling pathways

نویسندگان

Zhou Du

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Feng Zhou

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Zengrong Jia

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Beishi Zheng

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Shaoliang Han

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Jun Cheng

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Guanbao Zhu

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

Ping Huang

Office of Development and Planning, Wenzhou Medical University, Wenzhou ۳۲۵۰۳۵, Zhejiang Province, China

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