Effect of magnesium sulfate on hyperthermia and pentylen-tetrazol-induced seizure in developing rats
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 6
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 145
فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-19-6_005
تاریخ نمایه سازی: 30 مهر 1400
چکیده مقاله:
Objective(s): Febrile seizures (FS) are the most common type of convulsive events among children. Its prevalence has been estimated to be ۲-۵% in children between ۳ months and ۵ years old. Also, blood and CSF magnesium levels have been demonstrated to be reduced in children with FS. This study investigates the effect of MgSo۴ pretreatment on the behaviors caused by hyperthermia (HT) and effect of these two on pentylen-tetrazol (PTZ)-induced seizure later in life. Materials and Methods: Thirty two Wistar rats were assigned to ۲ groups: saline-hyperthermia-pentylentetrazol (SHP) and magnesium-hyperthermia-pentylentetrazol (MHP). In both groups, HT was induced at the age of ۱۸-۱۹ days old. Before the HT, MHP group received MgSo۴ and SHP group received normal saline intraperitoneally (IP). Behaviors of the rats were recorded during the HT. Then, in half of each group (n=۸) at the age of ۲۵-۲۶ days old and in other half at the age of ۷۸-۷۹ days, seizure was induced by PTZ. Results: The HT successfully caused convulsive behaviors in the rats and pretreatment with MgSo۴ before HT attenuated HT-induced convulsive behaviors. PTZ-induced seizures a week later was more severe than those of ۲ months later. Conclusion: It can be concluded that pretreatment with MgSO۴ inhibits HT-induced seizure and, in a long run, this intervention reduced PTZ-induced seizure later in life.
کلیدواژه ها:
نویسندگان
Maryam Ghadimkhani
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Ehsan Saboory
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran
Shiva Roshan-Milani
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Sedra Mohammdi
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Yousef Rasmi
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :