ورود
مقالات فارسیISIکنفرانسهاژورنالها

The effect of spinally administered WIN ۵۵,۲۱۲-۲, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 4
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 313

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1295951

شناسه ملی سند علمی:

JR_IJBMS-19-4_008

تاریخ نمایه سازی: 30 مهر 1400

چکیده مقاله:

Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN ۵۵,۲۱۲-۲, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Diabetes was induced in rats using a single dose of streptozotocin (۴۵ mg/kg IP). Results: Intrathecal (IT) administration of WIN۵۵, ۲۱۲-۲ (۱, ۱۰, ۱۰۰ µg/۱۰ µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (۱۰۰ µg/۱۰ µl, IT) and sciatic nerve histology. Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.

کلیدواژه ها:

Diabetes ، Intrathecal ، Neuropathy ، Pain ، WIN ۵۵ ، ۲۱۲-۲

نویسندگان

Samane Jahanabadi

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohamad Reza Hadian

Department of Physical Therapy, Faculty of Rehabilitation Sciences, Tehran University of Medical Sciences, Tehran, Iran

Javad Shamsaee

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyed Mohammad Tavangar

Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Alireza Abdollahi

Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Ahmadreza Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Shahram Ejtemaei Mehr

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Hohmann AG,Tsou K, Walker JM. Cannabinoid modulation of wide dynamic ...
  • Fox A, Kesingland A, Gentry C, McNair K, Patel S, ...
  • Tsou K, Brown S, Sanudo-Pena M, Mackie K, Walker J. ...
  • Hohmann A, Herkenham M. Localization of central cannabinoid CB۱ receptor ...
  • Hohmann A, Herkenham M. Cannabinoid receptors undergo axonal flow in ...
  • Martin WJ, Loo CM, Basbaum AI. Basbaum, Spinal cannabinoids are ...
  • Li J, Daughters RS, Bullis C, Bengiamin R, Stucky MW, ...
  • Costa B, Siniscalco D, Trovato AE, Comelli F, Sotgiu ML, ...
  • Liang YC, Huang CC, Hsu KS. The synthetic cannabinoids attenuate ...
  • Siegling A, Hofmann HA, Denzer D, Mauler F, De Vry ...
  • Bridges D, Thompson S, Rice A. Mechanisms of neuropathic pain. ...
  • Pertwee RG. Cannabis and cannabinoids: pharmacology and rationale for clinical ...
  • Rice A, Farquhar-Smith W, Nagy I. Endocannabinoids and pain: spinal ...
  • Vaughan CW, Christie MJ. An analgesic role for cannabinoids. Med ...
  • Scott DA, Wright CE, Angus JA. Evidence that CB-۱ and ...
  • Calignano A, La Rana G, Giuffrida A, Piomelli D. Control ...
  • Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, ...
  • Malan Jr TP, Ibrahim MM, Deng H, Liu Q, Mata ...
  • Malan TP, Ibrahim MM, Vanderah TW, Makriyannis A, Porreca F. ...
  • Bridges D, Ahmad K, Rice AS. The synthetic cannabinoid WIN۵۵, ...
  • Hanuš L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, ...
  • Ulugol A, Karadag HC, Ipci Y, Tamer M, Dokmeci I. ...
  • Mohammadi-Farani A, Sahebgharani M, Sepehrizadeh Z, Jaberi E, Ghazi-Khansari M. ...
  • Becker M, Benromano T, Shahar A, Nevo Z, Pick CG. ...
  • Kafri M, Drory VE, Wang N, Rabinowitz R, Korczyn AD, ...
  • Skundric DS, Lisak RP. Role of neuropoietic cytokines in development ...
  • Gerbi A, Maixent JM, Ansaldi JL, Pierlovisi M, Coste T, ...
  • Sima A, Prashar A, Nathaniel V, Bril V, Werb M, ...
  • Siemionow M, Demir Y. Diabetic neuropathy: pathogenesis and treatment. J ...
  • Peeraer E, Van Lutsenborg A, Verheyen A, de Jongh R, ...
  • Hohmann AG, Tsou K, Walker JM. Cannabinoid modulation of wide ...
  • Yang P, Wen H, Ou S, Cui J, Fan D. ...
  • Kang S, Kim CH, Lee H, Kim DY, Han JI, ...
  • Cui J, He W, Yi B, Zhao H, Lu K, ...
  • Doğrul A, Gül H, Yıldız O, Bilgin F, Güzeldemir ME. ...
  • Shabani M, Zangiabadi N, Asadi-Shekaari M. Evidence for positive effects ...
  • Manschot SM, Gispen WH, Kappelle LJ, Biessels GJ. Nerve conduction ...
  • Fox A, Eastwood C, Gentry C, Manning D, Urban L. ...
  • Ohsawa M, Mizoguchi H, Narita M, Narita M, Kamei J, ...
  • Mao J, Price D, Lu J, Keniston L, Mayer D. ...
  • Fuentes J, Ruiz-Gayo M, Manzanares J, Vela G, Reche I, ...
  • Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol ۲۰۰۱; ۶۳:۵۶۹-۶۱۱ ...
  • Walker JM, Huang SM. Cannabinoid analgesia. Pharmacol Therapeut ۲۰۰۲; ۹۵:۱۲۷-۱۳۵ ...
  • Herzberg U, Eliav E, Bennett G, Kopin IJ. The analgesic ...
  • Calcutt NA. Experimental models of painful diabetic neuropathy. J Neurol ...
  • Kakinoki B, Sekimoto S, Yuki S, Ohgami T, Sejima M, ...
  • Courteix C, Eschalier A, Lavarenne J. Streptozocin-induced diabetic rats: behavioural ...
  • Ulugol A, Karadag HC, Tamer M, Firat Z, Aslantas A, ...
  • Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol ...
  • Hohmann AG, Briley EM, Herkenham M. Pre-and postsynaptic distribution of ...
  • Iversen L, Chapman V. Cannabinoids: a real prospect for pain ...
  • Bridges D, Rice A, Egertova M, Elphick M, Winter J, ...
  • Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, ...
  • Hudson LJ, Bevan S, Wotherspoon G, Gentry C, Fox A, ...
  • Hohmann AG, Martin WJ, Tsou K, Walker JM. Inhibition of ...
    • نمایش کامل مراجع